| 9/3/2022 | McNeese State | 17 | at | Montana State (12-2) | 40 | at BSky | ||
| 9/10/2022 | McNeese State | 10 | at | Rice (5-8) | 52 | at CUSA | ||
| 9/17/2022 | Alcorn State (5-6) | 30 | at | McNeese State | 19 | SWAC | ||
| 9/24/2022 | Mississippi College (4-7) | 17 | at | McNeese State | 32 | GSC (D2) | ||
| 10/1/2022 | McNeese State | 20 | at | Incarnate Word (12-2,6-1) | 48 | |||
| 10/15/2022 | Texas A&M-Commerce (5-6,3-3) | 40 | at | McNeese State | 15 | |||
| 10/22/2022 | McNeese State | 35 | at | Nicholls State (3-8,3-4) | 40 | |||
| 10/29/2022 | Southeastern Louisiana (9-4,5-1) | 28 | at | McNeese State | 27 | |||
| 11/5/2022 | Eastern Illinois (2-9) | 15 | at | McNeese State | 29 | OVC | ||
| 11/12/2022 | McNeese State | 21 | at | Houston Christian (2-9,1-5) | 10 | |||
| 11/19/2022 | Lamar (1-10,1-5) | 20 | at | McNeese State | 24 |
| vs McNeese State | vs Other Opponents | McNeese State compared to OOs | |
| Record: | 7-4 | 53-67 | |
| Points Scored: | 30.91 | 28.92 | -1.99 |
| Points Allowed: | 22.64 | 30.79 | -8.15 |
| Margin: | 8.27 | -1.87 | -10.14 |
| Total Points: | 53.55 | 59.71 | -6.16 |