| 8/27/2022 | UNC-Charlotte | 13 | at | Florida Atlantic | 43 | |||
| North Texas | 31 | at | UTEP | 13 | ||||
| Austin Peay | 27 | at | Western Kentucky | 38 | ASUN (1AA) | |||
| 9/1/2022 | Alabama A&M | 0 | at | UAB | 59 | SWAC (1AA) | ||
| Bryant | 37 | at | Florida Intl | 38 | OT | BigS (1AA) | ||
| Louisiana Tech | 24 | at | Missouri | 52 | @ SEC | |||
| 9/2/2022 | William & Mary | 41 | at | UNC-Charlotte | 24 | CAAF (1AA) | ||
| 9/3/2022 | Western Kentucky | 49 | at | Hawaii | 17 | @ MW | ||
| Middle Tenn State | 7 | at | James Madison | 44 | @ SBC | |||
| SMU | 48 | at | North Texas | 10 | AAC | |||
| Florida Atlantic | 38 | at | Ohio | 41 | @ MAC | |||
| UTEP | 13 | at | Oklahoma | 45 | @ B12 | |||
| Rice | 14 | at | Southern California | 66 | @ P12 | |||
| Houston | 37 | at | Texas-San Antonio | 35 | 3OT | AAC | ||
| 9/10/2022 | Texas-San Antonio | 41 | at | Army | 38 | OT | @ Ind | |
| Middle Tenn State | 34 | at | Colorado State | 19 | @ MW | |||
| Southeastern Louisiana | 9 | at | Florida Atlantic | 42 | SLC (1AA) | |||
| UAB | 14 | at | Liberty | 21 | @ Ind | |||
| Stephen F. Austin | 17 | at | Louisiana Tech | 52 | WAC (1AA) | |||
| Texas Southern | 27 | at | North Texas | 59 | SWAC (1AA) | |||
| McNeese State | 10 | at | Rice | 52 | SLC (1AA) | |||
| Florida Intl | 12 | at | Texas State | 41 | @ SBC | |||
| Maryland | 56 | at | UNC-Charlotte | 21 | B10 | |||
| New Mexico State | 13 | at | UTEP | 20 | Ind | |||
| 9/17/2022 | Georgia Southern | 21 | at | UAB | 35 | SBC | ||
| Louisiana Tech | 20 | at | Clemson | 48 | @ ACC | |||
| UCF | 40 | at | Florida Atlantic | 14 | AAC | |||
| UNC-Charlotte | 42 | at | Georgia State | 41 | @ SBC | |||
| Western Kentucky | 30 | at | Indiana | 33 | @ B10 | |||
| Tennessee State | 6 | at | Middle Tenn State | 49 | OVC (1AA) | |||
| UTEP | 10 | at | New Mexico | 27 | @ MW | |||
| UL Lafayette | 21 | at | Rice | 33 | SBC | |||
| Texas-San Antonio | 20 | at | Texas | 41 | @ B12 | |||
| North Texas | 27 | at | UNLV | 58 | @ MW | |||
| 9/23/2022 | Boise State | 10 | at | UTEP | 27 | MW | ||
| 9/24/2022 | Rice | 27 | at | Houston | 34 | @ AAC | ||
| North Texas | 34 | at | Memphis | 44 | @ AAC | |||
| Middle Tenn State | 45 | at | Miami-Florida | 31 | @ ACC | |||
| Florida Atlantic | 26 | at | Purdue | 28 | @ B10 | |||
| Louisiana Tech | 14 | at | South Alabama | 38 | @ SBC | |||
| UNC-Charlotte | 20 | at | South Carolina | 56 | @ SEC | |||
| Texas Southern | 24 | at | Texas-San Antonio | 52 | SWAC (1AA) | |||
| Florida Intl | 0 | at | Western Kentucky | 73 | ||||
| 9/30/2022 | Texas-San Antonio | 45 | at | Middle Tenn State | 30 | |||
| 10/1/2022 | Florida Intl | 21 | at | New Mexico State | 7 | @ Ind | ||
| Florida Atlantic | 28 | at | North Texas | 45 | ||||
| UAB | 24 | at | Rice | 28 | ||||
| UTEP | 41 | at | UNC-Charlotte | 35 | ||||
| Troy | 34 | at | Western Kentucky | 27 | SBC | |||
| 10/8/2022 | Middle Tenn State | 14 | at | UAB | 41 | |||
| Connecticut | 33 | at | Florida Intl | 12 | Ind | |||
| UTEP | 31 | at | Louisiana Tech | 41 | ||||
| Western Kentucky | 28 | at | Texas-San Antonio | 31 | ||||
| 10/14/2022 | Texas-San Antonio | 30 | at | Florida Intl | 10 | |||
| 10/15/2022 | UNC-Charlotte | 20 | at | UAB | 34 | |||
| Rice | 14 | at | Florida Atlantic | 17 | ||||
| Western Kentucky | 35 | at | Middle Tenn State | 17 | ||||
| Louisiana Tech | 27 | at | North Texas | 47 | ||||
| 10/21/2022 | UAB | 17 | at | Western Kentucky | 20 | |||
| 10/22/2022 | Rice | 42 | at | Louisiana Tech | 41 | OT | ||
| North Texas | 27 | at | Texas-San Antonio | 31 | ||||
| Florida Intl | 34 | at | UNC-Charlotte | 15 | ||||
| Florida Atlantic | 21 | at | UTEP | 24 | ||||
| 10/28/2022 | Louisiana Tech | 34 | at | Florida Intl | 42 | 2OT | ||
| 10/29/2022 | UAB | 17 | at | Florida Atlantic | 24 | |||
| UNC-Charlotte | 56 | at | Rice | 23 | ||||
| Middle Tenn State | 24 | at | UTEP | 13 | ||||
| North Texas | 40 | at | Western Kentucky | 13 | ||||
| 11/3/2022 | UTEP | 30 | at | Rice | 37 | |||
| 11/5/2022 | Texas-San Antonio | 44 | at | UAB | 38 | 2OT | ||
| Middle Tenn State | 24 | at | Louisiana Tech | 40 | ||||
| Florida Intl | 14 | at | North Texas | 52 | ||||
| Western Kentucky | 59 | at | UNC-Charlotte | 7 | ||||
| 11/12/2022 | North Texas | 21 | at | UAB | 41 | |||
| Florida Atlantic | 52 | at | Florida Intl | 7 | ||||
| UNC-Charlotte | 14 | at | Middle Tenn State | 24 | ||||
| Louisiana Tech | 7 | at | Texas-San Antonio | 51 | ||||
| Rice | 10 | at | Western Kentucky | 45 | ||||
| 11/19/2022 | Western Kentucky | 17 | at | Auburn | 41 | @ SEC | ||
| UAB | 10 | at | LSU | 41 | @ SEC | |||
| Florida Atlantic | 21 | at | Middle Tenn State | 49 | ||||
| Texas-San Antonio | 41 | at | Rice | 7 | ||||
| Louisiana Tech | 21 | at | UNC-Charlotte | 26 | ||||
| Florida Intl | 6 | at | UTEP | 40 | ||||
| 11/26/2022 | Western Kentucky | 32 | at | Florida Atlantic | 31 | OT | ||
| Middle Tenn State | 33 | at | Florida Intl | 28 | ||||
| UAB | 37 | at | Louisiana Tech | 27 | ||||
| Rice | 17 | at | North Texas | 21 | ||||
| UTEP | 31 | at | Texas-San Antonio | 34 | ||||
| 12/2/2022 | North Texas | 27 | at | Texas-San Antonio | 48 | CUSA Championship | ||
| 12/16/2022 | Miami-Ohio | 20 | vs | UAB | 24 | Nassau BA | vs MAC | |
| Texas-San Antonio | 12 | vs | Troy | 18 | Orlando FL | vs SBC | ||
| 12/17/2022 | North Texas | 32 | vs | Boise State | 35 | Frisco TX | vs MW | |
| Rice | 24 | vs | Southern Miss | 38 | Mobile AL | vs SBC | ||
| 12/21/2022 | Western Kentucky | 44 | vs | South Alabama | 23 | New Orleans LA | vs SBC | |
| 12/24/2022 | Middle Tenn State | 25 | vs | San Diego State | 23 | Honolulu HI | vs MW |