| 9/3/2022 | Rice (5-8) | 14 | at | Southern California | 66 | CUSA | ||
| 9/10/2022 | Southern California | 41 | at | Stanford (3-9,1-8) | 28 | |||
| 9/17/2022 | Fresno State (10-4) | 17 | at | Southern California | 45 | MW | ||
| 9/24/2022 | Southern California | 17 | at | Oregon State (10-3,6-3) | 14 | |||
| 10/1/2022 | Arizona State (3-9,2-7) | 25 | at | Southern California | 42 | |||
| 10/8/2022 | Washington State (7-6,4-5) | 14 | at | Southern California | 30 | |||
| 10/15/2022 | Southern California | 42 | at | Utah (10-4,8-2) | 43 | |||
| 10/29/2022 | Southern California | 45 | at | Arizona (5-7,3-6) | 37 | |||
| 11/5/2022 | California (4-8,2-7) | 35 | at | Southern California | 41 | |||
| 11/11/2022 | Colorado (1-11,1-8) | 17 | at | Southern California | 55 | |||
| 11/19/2022 | Southern California | 48 | at | UCLA (9-4,6-3) | 45 | |||
| 11/26/2022 | Notre Dame (9-4) | 27 | at | Southern California | 38 | ND | ||
| 12/2/2022 | Utah (10-4,8-2) | 47 | vs | Southern California | 24 | Las Vegas NV | ||
| 1/2/2023 | Tulane (12-2) | 46 | vs | Southern California | 45 | Arlington TX | AAC |
| vs Southern California | vs Other Opponents | Southern California compared to OOs | |
| Record: | 3-11 | 93-72 | |
| Points Scored: | 29.21 | 30.45 | 1.24 |
| Points Allowed: | 41.36 | 26.37 | 14.99 |
| Margin: | -12.15 | 4.08 | 16.23 |
| Total Points: | 70.57 | 56.82 | 13.75 |