| 9/3/2022 | Houston | 37 | at | Texas-San Antonio (11-3) | 35 | 3OT | at CUSA | |
| 9/10/2022 | Houston | 30 | at | Texas Tech (8-5) | 33 | 2OT | at B12 | |
| 9/17/2022 | Kansas (6-7) | 48 | at | Houston | 30 | B12 | ||
| 9/24/2022 | Rice (5-8) | 27 | at | Houston | 34 | CUSA | ||
| 9/30/2022 | Tulane (12-2,8-1) | 27 | at | Houston | 24 | OT | ||
| 10/7/2022 | Houston | 33 | at | Memphis (7-6,3-5) | 32 | |||
| 10/22/2022 | Houston | 38 | at | Navy (4-8,4-4) | 20 | |||
| 10/29/2022 | South Florida (1-11,0-8) | 27 | at | Houston | 42 | |||
| 11/5/2022 | Houston | 63 | at | SMU (7-6,5-3) | 77 | |||
| 11/12/2022 | Temple (3-9,1-7) | 36 | at | Houston | 43 | |||
| 11/19/2022 | Houston | 42 | at | East Carolina (8-5,4-4) | 3 | |||
| 11/26/2022 | Tulsa (5-7,3-5) | 37 | at | Houston | 30 | |||
| 12/23/2022 | UL Lafayette (6-7) | 16 | vs | Houston | 23 | Shreveport LA | SBC |
| vs Houston | vs Other Opponents | Houston compared to OOs | |
| Record: | 5-8 | 78-76 | |
| Points Scored: | 32.15 | 30.99 | -1.16 |
| Points Allowed: | 36.08 | 28.90 | 7.18 |
| Margin: | -3.93 | 2.09 | 6.02 |
| Total Points: | 68.23 | 59.89 | 8.34 |