| 9/3/2022 | Nicholls State (3-8) | 7 | at | South Alabama | 48 | SLC (1AA) | ||
| 9/10/2022 | South Alabama | 38 | at | Central Michigan (4-8) | 24 | at MAC | ||
| 9/17/2022 | South Alabama | 31 | at | UCLA (9-4) | 32 | at P12 | ||
| 9/24/2022 | Louisiana Tech (3-9) | 14 | at | South Alabama | 38 | CUSA | ||
| 10/1/2022 | South Alabama | 20 | at | UL Lafayette (6-7,4-4) | 17 | |||
| 10/15/2022 | UL Monroe (4-8,3-5) | 34 | at | South Alabama | 41 | |||
| 10/20/2022 | Troy (12-2,8-1) | 10 | at | South Alabama | 6 | |||
| 10/29/2022 | South Alabama | 31 | at | Arkansas State (3-9,1-7) | 3 | |||
| 11/5/2022 | South Alabama | 38 | at | Georgia Southern (6-7,3-5) | 31 | |||
| 11/12/2022 | Texas State (4-8,2-6) | 21 | at | South Alabama | 38 | |||
| 11/19/2022 | South Alabama | 27 | at | Southern Miss (7-6,4-4) | 20 | |||
| 11/26/2022 | Old Dominion (3-9,2-6) | 20 | at | South Alabama | 27 | |||
| 12/21/2022 | Western Kentucky (9-5) | 44 | vs | South Alabama | 23 | New Orleans LA | CUSA |
| vs South Alabama | vs Other Opponents | South Alabama compared to OOs | |
| Record: | 3-10 | 70-80 | |
| Points Scored: | 21.31 | 27.32 | 6.01 |
| Points Allowed: | 31.23 | 27.73 | 3.50 |
| Margin: | -9.92 | -0.41 | 9.51 |
| Total Points: | 52.54 | 55.05 | -2.51 |