| 9/3/2022 | Texas Southern | 23 | at | Prairie View (6-5,5-3) | 40 | |||
| 9/10/2022 | Texas Southern | 27 | at | North Texas (7-7) | 59 | at CUSA | ||
| 9/17/2022 | Southern (7-5,5-4) | 0 | vs | Texas Southern | 24 | Arlington TX | ||
| 9/24/2022 | Texas Southern | 24 | at | Texas-San Antonio (11-3) | 52 | at CUSA | ||
| 10/1/2022 | Alabama State (6-5,4-4) | 16 | at | Texas Southern | 13 | |||
| 10/8/2022 | Texas Southern | 24 | at | Ark Pine Bluff (3-8,1-7) | 17 | |||
| 10/22/2022 | Texas Southern | 34 | at | Alcorn State (5-6,4-4) | 27 | |||
| 10/29/2022 | Lincoln CA (2-9) | 2 | at | Texas Southern | 37 | None (Unk?) | ||
| 11/5/2022 | Jackson State (12-1,10-0) | 41 | at | Texas Southern | 14 | |||
| 11/12/2022 | Grambling (3-8,2-7) | 7 | at | Texas Southern | 41 | |||
| 11/19/2022 | Texas Southern | 20 | at | Alabama A&M (4-7,4-4) | 24 |
| vs Texas Southern | vs Other Opponents | Texas Southern compared to OOs | |
| Record: | 6-5 | 60-59 | |
| Points Scored: | 25.91 | 27.09 | 1.18 |
| Points Allowed: | 25.55 | 27.86 | -2.31 |
| Margin: | 0.36 | -0.77 | -1.13 |
| Total Points: | 51.46 | 54.95 | -3.49 |