| 9/2/2022 | William & Mary | 41 | at | UNC-Charlotte (3-9) | 24 | at CUSA | ||
| 9/10/2022 | Campbell (5-6) | 21 | at | William & Mary | 37 | BigS | ||
| 9/17/2022 | William & Mary | 34 | at | Lafayette (4-7) | 7 | at Pat | ||
| 9/24/2022 | Elon (8-4,6-2) | 35 | at | William & Mary | 31 | |||
| 10/1/2022 | William & Mary | 27 | at | Stony Brook (2-9,1-7) | 10 | |||
| 10/8/2022 | Delaware (8-5,4-4) | 21 | at | William & Mary | 27 | |||
| 10/22/2022 | William & Mary | 44 | at | Towson (6-5,4-4) | 24 | |||
| 10/29/2022 | Rhode Island (7-4,5-3) | 30 | at | William & Mary | 31 | |||
| 11/5/2022 | William & Mary | 20 | at | Hampton (4-7,1-7) | 14 | |||
| 11/12/2022 | Villanova (6-5,4-4) | 12 | at | William & Mary | 45 | |||
| 11/19/2022 | William & Mary | 37 | at | Richmond (9-4,6-2) | 26 | |||
| 12/3/2022 | Gardner-Webb (7-6) | 14 | at | William & Mary | 54 | FCS Playoffs Round 2 | BigS | |
| 12/9/2022 | William & Mary | 7 | at | Montana State (12-2) | 55 | FCS Quarterful | at BSky |
| vs William & Mary | vs Other Opponents | William & Mary compared to OOs | |
| Record: | 2-11 | 79-62 | |
| Points Scored: | 22.54 | 27.15 | 4.61 |
| Points Allowed: | 33.46 | 25.94 | 7.52 |
| Margin: | -10.92 | 1.21 | 12.13 |
| Total Points: | 56.00 | 53.09 | 2.91 |