| 9/3/2022 | Tennessee State | 29 | at | Eastern Washington (3-8) | 36 | at BSky | ||
| 9/10/2022 | Jackson State (12-1) | 16 | vs | Tennessee State | 3 | Memphis TN | SWAC | |
| 9/17/2022 | Tennessee State | 6 | at | Middle Tenn State (8-5) | 49 | at CUSA | ||
| 10/1/2022 | Lane (5-5) | 28 | at | Tennessee State | 27 | OT | SIAC (D2) | |
| 10/8/2022 | Bethune-Cookman (2-9) | 17 | at | Tennessee State | 41 | SWAC | ||
| 10/15/2022 | Tennessee State | 30 | at | Tennessee Tech (4-7,2-3) | 14 | |||
| 10/22/2022 | Eastern Illinois (2-9,1-5) | 17 | at | Tennessee State | 37 | |||
| 10/29/2022 | Tennessee State | 3 | at | Murray State (2-9,1-4) | 19 | |||
| 11/5/2022 | SE Missouri State (9-3,5-0) | 42 | at | Tennessee State | 0 | |||
| 11/12/2022 | Tennessee-Martin (7-4,5-0) | 20 | at | Tennessee State | 3 | |||
| 11/19/2022 | Tennessee State | 22 | at | Texas A&M-Commerce (5-6) | 14 | at SLC |
| vs Tennessee State | vs Other Opponents | Tennessee State compared to OOs | |
| Record: | 7-4 | 52-62 | |
| Points Scored: | 24.73 | 28.19 | 3.46 |
| Points Allowed: | 18.27 | 30.15 | -11.88 |
| Margin: | 6.46 | -1.96 | -8.42 |
| Total Points: | 43.00 | 58.34 | -15.34 |