| 9/3/2022 | Bethune-Cookman (2-9) | 13 | at | Miami-Florida | 70 | SWAC (1AA) | ||
| 9/10/2022 | Southern Miss (7-6) | 7 | at | Miami-Florida | 30 | SBC | ||
| 9/17/2022 | Miami-Florida | 9 | at | Texas A&M (5-7) | 17 | at SEC | ||
| 9/24/2022 | Middle Tenn State (8-5) | 45 | at | Miami-Florida | 31 | CUSA | ||
| 10/8/2022 | North Carolina (9-5,6-3) | 27 | at | Miami-Florida | 24 | |||
| 10/15/2022 | Miami-Florida | 20 | at | Virginia Tech (3-8,1-6) | 14 | |||
| 10/22/2022 | Duke (9-4,5-3) | 45 | at | Miami-Florida | 21 | |||
| 10/29/2022 | Miami-Florida | 14 | at | Virginia (3-7,1-6) | 12 | 4OT | ||
| 11/5/2022 | Florida State (10-3,5-3) | 45 | at | Miami-Florida | 3 | |||
| 11/12/2022 | Miami-Florida | 35 | at | Georgia Tech (5-7,4-4) | 14 | |||
| 11/19/2022 | Miami-Florida | 10 | at | Clemson (11-3,9-0) | 40 | |||
| 11/26/2022 | Pittsburgh (9-4,5-3) | 42 | at | Miami-Florida | 16 |
| vs Miami-Florida | vs Other Opponents | Miami-Florida compared to OOs | |
| Record: | 7-5 | 74-63 | |
| Points Scored: | 26.75 | 27.39 | 0.64 |
| Points Allowed: | 23.58 | 25.68 | -2.10 |
| Margin: | 3.17 | 1.71 | -1.46 |
| Total Points: | 50.33 | 53.07 | -2.74 |