| 9/3/2022 | Memphis | 23 | at | Mississippi State (9-4) | 49 | at SEC | ||
| 9/10/2022 | Memphis | 37 | at | Navy (4-8,4-4) | 13 | |||
| 9/17/2022 | Arkansas State (3-9) | 32 | at | Memphis | 44 | SBC | ||
| 9/24/2022 | North Texas (7-7) | 34 | at | Memphis | 44 | CUSA | ||
| 10/1/2022 | Temple (3-9,1-7) | 3 | at | Memphis | 24 | |||
| 10/7/2022 | Houston (8-5,5-3) | 33 | at | Memphis | 32 | |||
| 10/15/2022 | Memphis | 45 | at | East Carolina (8-5,4-4) | 47 | 4OT | ||
| 10/22/2022 | Memphis | 28 | at | Tulane (12-2,8-1) | 38 | |||
| 11/5/2022 | UCF (9-5,6-3) | 35 | at | Memphis | 28 | |||
| 11/10/2022 | Tulsa (5-7,3-5) | 10 | at | Memphis | 26 | |||
| 11/19/2022 | North Alabama (1-10) | 0 | at | Memphis | 59 | ASUN (1AA) | ||
| 11/26/2022 | Memphis | 31 | at | SMU (7-6,5-3) | 34 | |||
| 12/27/2022 | Memphis | 38 | vs | Utah State (6-7) | 10 | Dallas TX | vs MW |
| vs Memphis | vs Other Opponents | Memphis compared to OOs | |
| Record: | 6-7 | 76-77 | |
| Points Scored: | 26.00 | 30.60 | 4.60 |
| Points Allowed: | 35.31 | 28.87 | 6.44 |
| Margin: | -9.31 | 1.73 | 11.04 |
| Total Points: | 61.31 | 59.47 | 1.84 |