| 9/2/2022 | Illinois (8-5,5-4) | 20 | at | Indiana | 23 | |||
| 9/10/2022 | Idaho (7-5) | 22 | at | Indiana | 35 | BSky (1AA) | ||
| 9/17/2022 | Western Kentucky (9-5) | 30 | at | Indiana | 33 | CUSA | ||
| 9/24/2022 | Indiana | 24 | at | Cincinnati (9-4) | 45 | at AAC | ||
| 10/1/2022 | Indiana | 21 | at | Nebraska (4-8,3-6) | 35 | |||
| 10/8/2022 | Michigan (13-1,10-0) | 31 | at | Indiana | 10 | |||
| 10/15/2022 | Maryland (8-5,4-5) | 38 | at | Indiana | 33 | |||
| 10/22/2022 | Indiana | 17 | at | Rutgers (4-8,1-8) | 24 | |||
| 11/5/2022 | Penn State (11-2,7-2) | 45 | at | Indiana | 14 | |||
| 11/12/2022 | Indiana | 14 | at | Ohio State (11-2,8-1) | 56 | |||
| 11/19/2022 | Indiana | 39 | at | Michigan State (5-7,3-6) | 31 | 2OT | ||
| 11/26/2022 | Purdue (8-6,6-4) | 30 | at | Indiana | 16 |
| vs Indiana | vs Other Opponents | Indiana compared to OOs | |
| Record: | 8-4 | 89-54 | |
| Points Scored: | 33.92 | 30.39 | -3.53 |
| Points Allowed: | 23.25 | 22.50 | 0.75 |
| Margin: | 10.67 | 7.89 | -2.78 |
| Total Points: | 57.17 | 52.89 | 4.28 |