| Thursday, 11 Sep 2008 |
| GSC | West Alabama (D2) | 24 | @ | Arkansas Tech (D2) | 26 | | |
| SW Minnesota St (D2) | 21 | @ | Minnesota-Duluth (D2) | 43 | | |
| North Greenville (D2) | 3 | @ | Newberry (D2) | 41 | | |
| North Carolina | 44 | @ | Rutgers | 12 | | |
| OVC | Tennessee Tech | 29 | @ | SE Missouri St | 27 | | |
| MSFA | St Francis IL (NAIA) | 24 | @ | St Xavier (NAIA) | 21 | | |
| Concordia AL (NAIA) | 21 | @ | Tennessee-Martin | 87 | | |
| Texas Lutheran (D3) | 0 | @ | Trinity TX (D3) | 24 | | |
| Friday, 12 Sep 2008 |
| Washington St | 17 | @ | Baylor | 45 | | |
| Carson-Newman (D2) | 59 | @ | Bentley (D2) | 18 | | |
| Alabama A&M | 15 | @ | Louisiana-Monroe | 37 | | |
| Southern Nazarene (NAIA) | 7 | @ | Mary Hardin-Baylor (D3) | 30 | | |
| NEF | Framingham St (D3) | 6 | @ | Nichols (D3) | 26 | | |
| #19 Kansas | 34 | @ | #14 South Florida | 37 | | |
| NE10 | American Int'l (D2) | 13 | @ | Southern Conn St (D2) | 12 | | |
| Albright (D3) | 30 | @ | Western Conn St (D3) | 27 | | |
| Saturday, 13 Sep 2008 |
| LSC | TAMU-Commerce (D2) | 14 | @ | Abilene Christian (D2) | 45 | | |
| RMAC | Chadron St (D2) | 37 | @ | Adams St (D2) | 26 | | |
| Defiance (D3) | 0 | @ | Adrian (D3) | 20 | | |
| MAC | Ball St | 41 | @ | Akron | 24 | | |
| Western Kentucky | 7 | @ | #14 Alabama | 41 | | |
| Thiel (D3) | 0 | @ | Albion (D3) | 16 | | |
| FDU-Florham (D3) | 14 | @ | Alfred (D3) | 21 | | |
| Virginia-Wise (NAIA) | 42 | @ | Apprentice (D3) | 0 | | |
| UNLV | 23 | @ | Arizona St | 20 | OT | |
| Southern Miss | 27 | @ | Arkansas St | 24 | | |
| Central Arkansas | 41 | vs | Arkansas-Pine Bluff | 17 | | Little Rock AR |
| Wartburg (D3) | 24 | @ | Augsburg (D3) | 30 | | |
| Greenville (D3) | 0 | @ | Augustana IL (D3) | 30 | | |
| ASWC | McMurry (D3) | 14 | @ | Austin (D3) | 21 | | |
| Gardner-Webb | 31 | @ | Austin Peay | 15 | | |
| Millsaps (D3) | 34 | @ | Belhaven (NAIA) | 14 | | |
| HAAC | MidAmerica Nazarene (NAIA) | 26 | @ | Benedictine KS (NAIA) | 23 | | |
| KCAC | McPherson (NAIA) | 37 | @ | Bethany KS (NAIA) | 21 | | |
| Kentucky Christian (NAIA) | 19 | @ | Bethany WV (D3) | 34 | | |
| KCAC | Kansas Wesleyan (NAIA) | 6 | @ | Bethel KS (NAIA) | 17 | | |
| NW Oklahoma St (NAIA) | 10 | @ | Black Hills St (NAIA) | 7 | | |
| UMWAC | Maranatha Baptist (D3) | 7 | @ | Blackburn (D3) | 20 | | |
| Mercyhurst (D2) | 0 | @ | Bloomsburg (D2) | 24 | | |
| Bowling Green | 7 | @ | Boise St | 20 | | |
| GPAC | Hastings (NAIA) | 24 | @ | Briar Cliff (NAIA) | 25 | | |
| NEF | UMass-Dartmouth (D3) | 32 | @ | Bridgewater St MA (D3) | 27 | | |
| Shenandoah (D3) | 10 | @ | Bridgewater VA (D3) | 6 | | |
| UCLA | 0 | @ | #10 Brigham Young | 59 | | |
| NE10 | Merrimack (D2) | 7 | @ | Bryant (D2) | 20 | | |
| MAC | Temple | 28 | @ | Buffalo | 30 | | |
| Franklin (D3) | 31 | @ | Butler | 28 | | |
| Edinboro (D2) | 31 | @ | C.W. Post (D2) | 7 | | |
| Willamette (D3) | 31 | @ | Cal Lutheran (D3) | 17 | | |
| Lake Erie (D2) | 0 | @ | California PA (D2) | 54 | | |
| Ohio Dominican (NAIA) | 50 | @ | Campbellsville (NAIA) | 14 | | |
| Front | Rocky Mountain (NAIA) | 14 | @ | Carroll MT (NAIA) | 47 | | |
| MidW | Beloit (D3) | 0 | @ | Carroll WI (D3) | 10 | | |
| Hope (D3) | 46 | @ | Carthage (D3) | 70 | | |
| Rochester (D3) | 6 | @ | Case Western Reserve (D3) | 38 | | |
| Franklin & Marshall (D3) | 7 | @ | Catholic (D3) | 14 | | |
| LSC | TAMU-Kingsville (D2) | 41 | @ | Central Oklahoma (D2) | 6 | | |
| Gannon (D2) | 40 | @ | Cheyney (D2) | 18 | | |
| Kenyon (D3) | 39 | @ | Chicago (D3) | 36 | | |
| D2Ind | Brevard (D2) | 20 | @ | Chowan (D2) | 23 | | |
| Lewis & Clark (D3) | 17 | @ | Claremont-Mudd-Scripps (D3) | 41 | | |
| PSAC | East Stroudsburg (D2) | 49 | @ | Clarion (D2) | 28 | | |
| Stillman (D2) | 36 | @ | Clark Atlanta (D2) | 48 | | |
| ACC | North Carolina St | 9 | @ | Clemson | 27 | | |
| Gustavus Adolphus (D3) | 27 | @ | Coe (D3) | 19 | | |
| Furman | 42 | @ | Colgate | 21 | | |
| Occidental (D3) | 41 | @ | Colorado College (D3) | 0 | | |
| RMAC | Western New Mexico (D2) | 28 | @ | Colorado Mines (D2) | 35 | | |
| WVIAC | West Liberty St (D2) | 38 | @ | Concord (D2) | 20 | | |
| Dickinson St (NAIA) | 13 | @ | Concordia-Moorhead (D3) | 38 | | |
| NSIC | Minn St-Moorhead (D3) | 23 | @ | Concordia-St Paul (D2) | 27 | | |
| Virginia | 10 | @ | Connecticut | 45 | | |
| Carleton (D3) | 38 | @ | Cornell IA (D3) | 14 | | |
| HAAC | Baker (NAIA) | 28 | @ | Culver-Stockton (NAIA) | 0 | | |
| Mississippi College (D3) | 28 | @ | Cumberlands KY (NAIA) | 49 | | |
| NEF | Fitchburg St (D3) | 34 | @ | Curry (D3) | 41 | | |
| GPAC | Nebraska Wesleyan (NAIA) | 7 | @ | Dakota Wesleyan (NAIA) | 27 | | |
| Fordham | 20 | @ | Dayton | 23 | | |
| West Chester (D2) | 20 | @ | Delaware | 48 | | |
| Wesley (D3) | 22 | @ | Delaware Valley (D3) | 25 | | |
| GSC | Arkansas-Monticello (D2) | 31 | @ | Delta St (D2) | 37 | | |
| NCA | Wabash (D3) | 41 | @ | Denison (D3) | 27 | | |
| Anderson (D3) | 17 | @ | DePauw (D3) | 52 | | |
| GPAC | Concordia NE (NAIA) | 13 | @ | Doane (NAIA) | 29 | | |
| William Penn (NAIA) | 0 | @ | Drake | 36 | | |
| Navy | 31 | @ | Duke | 41 | | |
| LSC | Tarleton St (D2) | 38 | @ | East Central OK (D2) | 6 | | |
| Indiana St | 3 | @ | Eastern Illinois | 38 | | |
| Morehead St | 8 | @ | Eastern Kentucky | 16 | | |
| MAC | Toledo | 41 | @ | Eastern Michigan | 17 | | |
| Presbyterian | 12 | @ | Elon | 66 | | |
| Greensboro (D3) | 14 | @ | Emory & Henry (D3) | 12 | | |
| RPI (D3) | 36 | @ | Endicott (D3) | 7 | | |
| IBC | Concordia IL (D3) | 8 | @ | Eureka (D3) | 28 | | |
| WVIAC | West Virginia St (D2) | 21 | @ | Fairmont St (D2) | 20 | | |
| Huntingdon (D3) | 21 | @ | Faulkner (NAIA) | 7 | | |
| GLIAC | Findlay (D2) | 0 | @ | Ferris St (D2) | 14 | | |
| Southern Virginia (NAIA) | 7 | @ | Ferrum (D3) | 34 | | |
| Chattanooga | 7 | @ | Florida St | 46 | | |
| Washburn (D2) | 7 | @ | Fort Hays St (D2) | 17 | | |
| RMAC | Colorado St-Pueblo (D2) | 37 | @ | Fort Lewis (D2) | 7 | | |
| Virginia Union (D2) | 27 | @ | Fort Valley St (D2) | 2 | | |
| #12 Wisconsin | 13 | @ | Fresno St | 10 | | |
| St Vincent (D3) | 23 | @ | Gallaudet (D3) | 22 | | |
| MSC | Cumberland TN (NAIA) | 14 | @ | Georgetown KY (NAIA) | 45 | | |
| Northeastern | 27 | @ | Georgia Southern | 34 | OT | |
| Hampden-Sydney (D3) | 45 | @ | Gettysburg (D3) | 40 | | |
| HAAC | Missouri Valley (NAIA) | 48 | @ | Graceland (NAIA) | 15 | | |
| Midland Lutheran (NAIA) | 48 | vs | Grand View (NAIA) | 37 | | Johnston IA |
| Carnegie Mellon (D3) | 10 | @ | Grove City (D3) | 19 | | |
| Methodist (D3) | 33 | @ | Guilford (D3) | 34 | | |
| MEAC | Howard | 27 | @ | Hampton | 38 | | |
| Waynesburg (D3) | 34 | @ | Hanover (D3) | 32 | | |
| Linfield (D3) | 22 | @ | Hardin-Simmons (D3) | 29 | | |
| GLIAC | Northwood (D2) | 7 | @ | Hillsdale (D2) | 26 | | |
| Dickinson (D3) | 21 | @ | Hobart (D3) | 28 | | |
| Albany NY | 22 | @ | Hofstra | 16 | OT | |
| Air Force | 31 | vs | Houston | 28 | | Dallas TX |
| Texas College (NAIA) | 13 | @ | Howard Payne (D3) | 20 | | |
| Western Washington (D2) | 30 | @ | Humboldt St (D2) | 14 | | |
| Utica (D3) | 17 | @ | Husson (D3) | 34 | | |
| Western Michigan | 51 | @ | Idaho | 28 | | |
| Louisiana-Lafayette | 17 | @ | Illinois | 20 | | |
| MidW | Knox (D3) | 27 | @ | Illinois College (D3) | 62 | | |
| Alma (D3) | 34 | @ | Illinois Wesleyan (D3) | 48 | | |
| Iowa St | 5 | @ | Iowa | 17 | | |
| Pio | Campbell | 0 | @ | Jacksonville FL | 52 | | |
| CAAF | Massachusetts | 38 | @ | James Madison | 52 | | |
| Edward Waters (NAIA) | 31 | @ | Johnson C. Smith (D2) | 37 | | |
| Delaware St | 3 | @ | Kent St | 24 | | |
| Middle Tennessee St | 14 | @ | Kentucky | 20 | | |
| SIAC | Albany St GA (D2) | 41 | @ | Kentucky St (D2) | 27 | | |
| Ithaca (D3) | 38 | @ | King's PA (D3) | 28 | | |
| Pat | Georgetown DC | 6 | @ | Lafayette | 24 | | |
| Shorter (NAIA) | 28 | @ | LaGrange (D3) | 23 | | |
| Mt St Joseph (D3) | 20 | @ | Lakeland (D3) | 0 | | |
| D2Ind | OK Panhandle St (D2) | 2 | @ | Langston (D2) | 35 | | |
| Davidson | 20 | @ | Lenoir-Rhyne (D2) | 16 | | |
| CIAA | Fayetteville St (D2) | 63 | @ | Lincoln PA (D2) | 0 | | |
| HAAC | Avila (NAIA) | 9 | @ | Lindenwood (NAIA) | 59 | | |
| Catawba (D2) | 49 | @ | Livingstone (D2) | 7 | | |
| PSAC | Shippensburg (D2) | 36 | @ | Lock Haven (D2) | 0 | | |
| North Texas | 3 | @ | #7 LSU | 41 | | |
| Crown (NAIA) | 7 | @ | Macalester (D3) | 17 | | |
| IBC | Aurora (D3) | 30 | @ | MacMurray (D3) | 18 | | |
| Stony Brook | 13 | @ | Maine | 28 | | |
| Becker (D3) | 34 | @ | Maine Maritime (D3) | 32 | | |
| Earlham (D3) | 7 | @ | Manchester (D3) | 40 | | |
| CUSA | Memphis | 16 | @ | Marshall | 17 | | |
| Hamline (D3) | 19 | @ | Martin Luther (NAIA) | 13 | | |
| California | 27 | @ | Maryland | 35 | | |
| Centre (D3) | 17 | @ | Maryville (D3) | 20 | | |
| Moravian (D3) | 42 | @ | McDaniel (D3) | 3 | | |
| MSFA | Marian (NAIA) | 28 | @ | McKendree (NAIA) | 21 | | |
| D3Ind | Chapman (D3) | 31 | @ | Menlo (D3) | 6 | | |
| LL | Coast Guard (D3) | 7 | @ | Merchant Marine (D3) | 34 | | |
| RMAC | New Mexico Highlands (D2) | 27 | @ | Mesa St (D2) | 34 | | |
| Charleston Southern | 27 | @ | Miami OH | 38 | | |
| Florida Atlantic | 0 | @ | Michigan St | 17 | | |
| GLIAC | Ashland (D2) | 48 | @ | Michigan Tech (D2) | 41 | | |
| PSAC | Indiana PA (D2) | 63 | @ | Millersville (D2) | 3 | | |
| Loras (D3) | 31 | @ | Millikin (D3) | 14 | | |
| Mary (D2) | 0 | @ | Minn St-Mankato (D2) | 40 | | |
| Montana St | 23 | @ | Minnesota | 35 | | |
| Augustana SD (D2) | 59 | @ | Minnesota-Crookston (D2) | 0 | | |
| Dakota St (NAIA) | 40 | @ | Minnesota-Morris (NAIA) | 24 | | |
| Samford | 10 | @ | Mississippi | 34 | | |
| SEC | #10 Auburn | 3 | @ | Mississippi St | 2 | | |
| Nevada | 17 | @ | #8 Missouri | 69 | | |
| Evangel (NAIA) | 7 | @ | Missouri S&T (D2) | 41 | | |
| NEF | Mass Maritime (D3) | 14 | @ | MIT (D3) | 42 | | |
| MidW | Lawrence (D3) | 2 | @ | Monmouth IL (D3) | 47 | | |
| Coastal Carolina | 26 | @ | Monmouth NJ | 7 | | |
| Southern Utah | 10 | @ | Montana | 46 | | |
| Eastern Oregon (NAIA) | 7 | @ | Montana St-Northern (NAIA) | 24 | | |
| Front | Montana-Western (NAIA) | 17 | @ | Montana Tech (NAIA) | 21 | | |
| Wilkes (D3) | 6 | @ | Montclair St (D3) | 13 | | |
| SIAC | Lane (D2) | 24 | @ | Morehouse (D2) | 28 | | |
| North Carolina Central | 7 | @ | Morgan St | 49 | | |
| D3Ind | Plymouth St (D3) | 7 | @ | Mount Ida (D3) | 24 | | |
| Illinois St | 42 | @ | Murray St | 13 | | |
| New Mexico St | 7 | @ | Nebraska | 38 | | |
| Emporia St (D2) | 20 | @ | Nebraska-Omaha (D2) | 41 | | |
| Arizona | 28 | @ | New Mexico | 36 | | |
| MEAC | North Carolina A&T | 21 | @ | Norfolk St | 27 | | |
| GSC | Henderson St (D2) | 20 | @ | North Alabama (D2) | 45 | | |
| Ohio Northern (D3) | 3 | @ | North Central (D3) | 20 | | |
| UW-La Crosse (D3) | 7 | @ | North Dakota (D2) | 45 | | |
| Rose-Hulman (D3) | 10 | @ | North Park (D3) | 7 | | |
| LSC | Midwestern St (D2) | 7 | @ | Northeastern St OK (D2) | 3 | | |
| Upper Iowa (D2) | 31 | @ | Northern St SD (D2) | 26 | | |
| Southern Illinois | 7 | @ | Northwestern | 33 | | |
| GPAC | Morningside (NAIA) | 26 | @ | Northwestern IA (NAIA) | 21 | | |
| Simpson (D3) | 9 | @ | Northwestern MN (NAIA) | 6 | | |
| Michigan | 17 | @ | Notre Dame | 35 | | |
| MAIAA | Missouri Western (D2) | 35 | @ | NW Missouri St (D2) | 42 | | |
| MAC | Central Michigan | 31 | @ | Ohio U. | 28 | | |
| Missouri St | 13 | @ | Oklahoma St | 57 | | |
| Elmhurst (D3) | 31 | @ | Olivet (D3) | 14 | | |
| Hawaii | 7 | @ | Oregon St | 45 | | |
| KCAC | Tabor (NAIA) | 6 | @ | Ottawa (NAIA) | 52 | | |
| GSC | West Georgia (D2) | 17 | @ | Ouachita Baptist (D2) | 41 | | |
| NE10 | Stonehill (D2) | 24 | @ | Pace (D2) | 28 | | |
| Valley City St (NAIA) | 37 | @ | Peru St (NAIA) | 18 | | |
| MSC | Lambuth (NAIA) | 49 | @ | Pikeville (NAIA) | 27 | | |
| MAIAA | Missouri Southern (D2) | 14 | @ | Pittsburg St (D2) | 21 | | |
| Puget Sound (D3) | 37 | @ | Pomona-Pitzer (D3) | 7 | | |
| #11 Oregon | 32 | @ | Purdue | 26 | 2OT | |
| MSFA | St Francis IN (NAIA) | 21 | @ | Quincy (NAIA) | 0 | | |
| Johns Hopkins (D3) | 39 | @ | Randolph-Macon (D3) | 31 | | |
| Dubuque (D3) | 9 | @ | Redlands (D3) | 46 | | |
| CAAF | New Hampshire | 51 | @ | Rhode Island | 43 | | |
| CAAF | Towson | 14 | @ | Richmond | 45 | | |
| MidW | Lake Forest (D3) | 3 | @ | Ripon (D3) | 14 | | |
| Bucknell | 17 | @ | Robert Morris | 14 | | |
| Kalamazoo (D3) | 17 | @ | Rockford (D3) | 14 | | |
| Southern Oregon (NAIA) | 16 | @ | Sacramento St | 27 | | |
| GLIAC | Grand Valley St (D2) | 36 | @ | Saginaw Valley St (D2) | 0 | | |
| Geneva (NAIA) | 6 | @ | Salisbury (D3) | 48 | | |
| SUNY-Maritime (D3) | 14 | @ | Salve Regina (D3) | 46 | | |
| San Diego St | 10 | @ | San Jose St | 35 | | |
| South Dakota | 30 | @ | SE Louisiana St | 31 | | |
| LSC | Eastern New Mexico (D2) | 14 | @ | SE Oklahoma St (D2) | 29 | | |
| Washington and Lee (D3) | 24 | @ | Sewanee (D3) | 12 | | |
| WVIAC | Glenville St (D2) | 21 | @ | Shepherd (D2) | 14 | | |
| GPAC | Dana (NAIA) | 0 | @ | Sioux Falls (NAIA) | 70 | | |
| PSAC | Kutztown (D2) | 24 | @ | Slippery Rock (D2) | 38 | | |
| SEC | #5 Georgia | 14 | @ | South Carolina | 7 | | |
| MEAC | Bethune-Cookman | 19 | vs | South Carolina St | 28 | | Charleston SC |
| MVC | Western Illinois | 22 | @ | South Dakota St | 24 | | |
| #18 Ohio State | 3 | @ | #1 Southern Cal | 35 | | |
| SWAC | Mississippi Valley St | 7 | @ | Southern U. | 49 | | |
| KCAC | St Mary KS (NAIA) | 26 | @ | Southwestern KS (NAIA) | 20 | | |
| Union NY (D3) | 24 | @ | Springfield (D3) | 14 | | |
| UW-Platteville (D3) | 17 | @ | St Ambrose (NAIA) | 34 | | |
| Mars Hill (D2) | 31 | @ | St Augustine's (D2) | 13 | | |
| Wayne St NE (D2) | 17 | @ | St Cloud St (D2) | 31 | | |
| Marist | 30 | @ | St Francis PA | 22 | | |
| Buffalo St (D3) | 7 | @ | St John Fisher (D3) | 20 | | |
| UW-River Falls (D3) | 6 | @ | St John's MN (D3) | 22 | | |
| Norwich (D3) | 27 | @ | St Lawrence (D3) | 7 | | |
| MidW | Grinnell (D3) | 7 | @ | St Norbert (D3) | 55 | | |
| Pacific Lutheran (D3) | 0 | @ | St Olaf (D3) | 17 | | |
| KCAC | Friends (NAIA) | 33 | @ | Sterling (NAIA) | 7 | | |
| SW Assem of God (NAIA) | 14 | @ | Sul Ross St (D3) | 30 | | |
| MidAC | Juniata (D3) | 3 | @ | Susquehanna (D3) | 10 | | |
| Harding (D2) | 31 | @ | SW Baptist (D2) | 43 | | |
| LSC | Angelo St (D2) | 24 | @ | SW Oklahoma St (D2) | 2 | | |
| #13 Penn State | 55 | @ | Syracuse | 13 | | |
| MSFA | Olivet Nazarene (NAIA) | 27 | @ | Taylor (NAIA) | 20 | | |
| Stanford | 14 | @ | #17 TCU | 31 | | |
| Alabama-Birmingham | 3 | @ | Tennessee | 35 | | |
| Jackson St | 18 | vs | Tennessee St | 41 | | Memphis TN |
| Shaw (D2) | 29 | vs | Texas Southern | 40 | | Sacramento CA |
| SMU | 7 | @ | #19 Texas Tech | 43 | | |
| Northern Michigan (D2) | 28 | @ | Tiffin (D2) | 34 | | |
| South Dakota Tech (NAIA) | 70 | @ | Trinity Bible (NAIA) | 0 | | |
| Alcorn St | 0 | @ | Troy | 65 | | |
| MAIAA | Central Missouri (D2) | 31 | @ | Truman St (D2) | 28 | | |
| CUSA | #23 East Carolina | 28 | @ | Tulane | 24 | | |
| Elizabeth City St (D2) | 30 | @ | Tusculum (D2) | 32 | | |
| SIAC | Benedict (D2) | 14 | @ | Tuskegee (D2) | 37 | | |
| Portland St | 24 | @ | UC-Davis | 38 | | |
| Malone (NAIA) | 28 | @ | Union KY (NAIA) | 35 | | |
| Lebanon Valley (D3) | 31 | @ | Ursinus (D3) | 19 | | |
| #15 Utah | 58 | @ | Utah St | 10 | | |
| WIAC | UW-Whitewater (D3) | 16 | @ | UW-Eau Claire (D3) | 14 | | |
| Iowa Wesleyan (NAIA) | 7 | @ | UW-Stevens Point (D3) | 45 | | |
| Jamestown (NAIA) | 13 | @ | UW-Stout (D3) | 37 | | |
| Concordia WI (D3) | 10 | @ | Valparaiso | 34 | | |
| Rice | 21 | @ | Vanderbilt | 38 | | |
| Lehigh | 14 | @ | Villanova | 33 | | |
| St Joseph's IN (D2) | 43 | @ | Virginia St (D2) | 36 | | |
| ACC | Georgia Tech | 17 | @ | #24 Virginia Tech | 20 | | |
| Iona | 28 | @ | Wagner | 45 | | |
| Dordt (NAIA) | 13 | @ | Waldorf (NAIA) | 17 | | |
| Seton Hill (NAIA) | 23 | @ | Walsh (NAIA) | 21 | | |
| Frostburg St (D3) | 21 | @ | Wash & Jeff (D3) | 49 | | |
| #3 Oklahoma | 55 | @ | Washington | 14 | | |
| Westminster MO (D3) | 13 | @ | Washington U. (D3) | 45 | | |
| GLIAC | Indianapolis (D2) | 0 | @ | Wayne St MI (D2) | 6 | | |
| St Paul's (D2) | 13 | @ | Webber Int'l (NAIA) | 9 | | |
| Dixie St (D2) | 7 | @ | Weber St | 44 | | |
| Azusa Pacific (NAIA) | 13 | @ | West Texas A&M (D2) | 75 | | |
| Liberty | 19 | @ | Western Carolina | 16 | | |
| NEF | Westfield St (D3) | 23 | @ | Western New England (D3) | 21 | | |
| Central Washington (D2) | 31 | @ | Western Oregon (D2) | 24 | | |
| RMAC | Nebraska-Kearney (D2) | 44 | @ | Western St CO (D2) | 15 | | |
| Allegheny (D3) | 2 | @ | Westminster PA (D3) | 6 | | |
| Bethel MN (D3) | 7 | @ | Wheaton (D3) | 10 | | |
| Principia (D3) | 6 | @ | Whittier (D3) | 44 | | |
| La Verne (D3) | 13 | @ | Whitworth (D3) | 22 | | |
| North Carolina Wesleyan (D3) | 6 | @ | Widener (D3) | 7 | | |
| VMI | 17 | @ | William & Mary | 52 | | |
| HAAC | Central Methodist (NAIA) | 13 | @ | William Jewell (NAIA) | 24 | | |
| UNC-Pembroke (D2) | 16 | @ | Wingate (D2) | 23 | | |
| NSIC | Bemidji St (D2) | 7 | @ | Winona St (D2) | 31 | | |
| Savannah St | 16 | @ | Winston-Salem St | 13 | | |
| Mayville St (NAIA) | 9 | @ | Wisconsin Lutheran (D3) | 7 | | |
| Worcester St (D3) | 10 | @ | WPI (D3) | 31 | | |
| WVIAC | Charleston WV (D2) | 24 | @ | WV Wesleyan (D2) | 17 | | |
| North Dakota St | 13 | @ | Wyoming | 16 | | |
| Central St OH (D2) | 0 | @ | Youngstown St | 38 | | |
| Sunday, 14 Sep 2008 |
| CSFL | Bacone (NAIA) | 22 | @ | Haskell (NAIA) | 29 | | |
| Rhodes (D3) | 3 | @ | Louisiana College (D3) | 14 | | |
| Grambling St | 19 | @ | Northwestern St | 31 | | |
| Wednesday, 17 Sep 2008 |
| Kansas St | 29 | @ | Louisville | 38 | | |