| 8/28/2008 | Lambuth NAIA | 17 | @ | Murray St | 41 | ||||
| 9/6/2008 | Murray St | 3 | @ | Indiana | 45 | ||||
| 9/13/2008 | Illinois St | 42 | @ | Murray St | 13 | ||||
| 9/20/2008 | Murray St | 9 | @ | Western Kentucky | 50 | ||||
| 9/27/2008 | Tennessee-Martin | 63 | @ | Murray St | 38 | OVC | |||
| 10/4/2008 | Murray St | 32 | @ | Austin Peay | 12 | OVC | |||
| 10/11/2008 | Tennessee Tech | 21 | @ | Murray St | 51 | OVC | |||
| 10/18/2008 | Murray St | 21 | @ | Jacksonville St | 31 | OVC | |||
| 11/1/2008 | Murray St | 6 | @ | Eastern Illinois | 34 | OVC | |||
| 11/8/2008 | SE Missouri St | 10 | @ | Murray St | 17 | OVC | |||
| 11/15/2008 | Murray St | 7 | @ | Eastern Kentucky | 34 | OVC | |||
| 11/22/2008 | Tennessee St | 17 | @ | Murray St | 24 | OVC |