| 8/30/2008 | S Carolina St | 0 | @ | UCF | 17 | ||||
| 9/6/2008 | Benedict D2 | 3 | @ | S Carolina St | 42 | ||||
| 9/13/2008 | Bethune-Cookman | 19 | vs | S Carolina St | 28 | MEAC | |||
| 9/20/2008 | S Carolina St | 0 | @ | Clemson | 54 | ||||
| 9/27/2008 | S Carolina St | 43 | @ | Winston-Salem St | 17 | MEAC | |||
| 10/4/2008 | S Carolina St | 28 | @ | Florida A&M | 21 | MEAC | |||
| 10/11/2008 | Norfolk St | 23 | @ | S Carolina St | 24 | MEAC | |||
| 10/25/2008 | Hampton | 13 | @ | S Carolina St | 35 | MEAC | |||
| 11/1/2008 | S Carolina St | 23 | @ | Delaware St | 17 | MEAC | |||
| 11/6/2008 | Howard | 0 | @ | S Carolina St | 56 | MEAC | |||
| 11/15/2008 | S Carolina St | 32 | @ | Morgan St | 0 | MEAC | |||
| 11/22/2008 | S Carolina St | 55 | @ | NC A&T | 0 | MEAC | |||
| 11/29/2008 | S Carolina St | 21 | @ | Appalachian St | 37 | FCS championship round 1 |