| 9/6/2008 | Toledo | 16 | @ | Arizona | 41 | ||||
| 9/13/2008 | Toledo | 41 | @ | Eastern Michigan | 17 | MAC | |||
| 9/20/2008 | Fresno St | 55 | @ | Toledo | 54 | 2 OT | |||
| 9/27/2008 | Florida Intl | 35 | @ | Toledo | 16 | ||||
| 10/4/2008 | Ball State | 31 | @ | Toledo | 0 | MAC | |||
| 10/11/2008 | Toledo | 13 | @ | Michigan | 10 | ||||
| 10/18/2008 | Toledo | 7 | @ | Northern Illinois | 38 | MAC | |||
| 10/25/2008 | Central Michigan | 24 | @ | Toledo | 23 | MAC | |||
| 11/5/2008 | Toledo | 30 | @ | Akron | 47 | MAC | |||
| 11/15/2008 | Toledo | 17 | @ | Western Michigan | 27 | MAC | |||
| 11/21/2008 | Miami-Ohio | 14 | @ | Toledo | 42 | MAC | |||
| 11/28/2008 | Bowling Green | 38 | @ | Toledo | 10 | MAC |