| 9/4/2008 | Washburn D2 | 35 | @ | Missouri State | 27 | ||||
| 9/13/2008 | Missouri State | 13 | @ | Oklahoma St | 57 | ||||
| 10/4/2008 | Western Illinois | 33 | @ | Missouri State | 21 | MVC | |||
| 10/11/2008 | Youngstown St | 28 | @ | Missouri State | 42 | MVC | |||
| 10/18/2008 | Missouri State | 34 | @ | Illinois St | 28 | MVC | |||
| 10/25/2008 | Southern Illinois | 23 | @ | Missouri State | 17 | OT | MVC | ||
| 11/1/2008 | Missouri State | 13 | @ | S Dakota St | 43 | MVC | |||
| 11/8/2008 | Missouri State | 0 | @ | Northern Iowa | 42 | MVC | |||
| 11/15/2008 | N Dakota St | 48 | @ | Missouri State | 27 | ||||
| 11/22/2008 | Missouri State | 27 | @ | Indiana St | 24 | OT | MVC |