| 8/28/2008 | Eastern Illinois | 12 | @ | Central Michigan | 31 | ||||
| 9/6/2008 | Eastern Illinois | 21 | @ | Illinois | 47 | ||||
| 9/13/2008 | Indiana St | 3 | @ | Eastern Illinois | 38 | ||||
| 9/20/2008 | Eastern Illinois | 25 | @ | Illinois St | 21 | ||||
| 9/27/2008 | Jacksonville St | 23 | @ | Eastern Illinois | 10 | OT | OVC | ||
| 10/9/2008 | Eastern Illinois | 26 | @ | Tennessee-Martin | 29 | OVC | |||
| 10/18/2008 | SE Missouri St | 21 | @ | Eastern Illinois | 24 | OVC | |||
| 10/25/2008 | Eastern Illinois | 7 | @ | Eastern Kentucky | 20 | OVC | |||
| 11/1/2008 | Murray St | 6 | @ | Eastern Illinois | 34 | OVC | |||
| 11/8/2008 | Eastern Illinois | 24 | @ | Tennessee St | 45 | OVC | |||
| 11/15/2008 | Austin Peay | 15 | @ | Eastern Illinois | 13 | OVC | |||
| 11/22/2008 | Eastern Illinois | 38 | @ | Tennessee Tech | 20 | OVC |