| 9/6/2008 | Winston-Salem St | 8 | @ | NC A&T | 14 | MEAC | |||
| 9/13/2008 | Savannah St | 16 | @ | Winston-Salem St | 13 | ||||
| 9/20/2008 | Morgan St | 21 | @ | Winston-Salem St | 7 | MEAC | |||
| 9/27/2008 | S Carolina St | 43 | @ | Winston-Salem St | 17 | MEAC | |||
| 10/4/2008 | Howard | 10 | @ | Winston-Salem St | 34 | MEAC | |||
| 10/9/2008 | Winston-Salem St | 0 | @ | Florida A&M | 23 | MEAC | |||
| 10/25/2008 | Bethune-Cookman | 27 | @ | Winston-Salem St | 6 | MEAC | |||
| 11/1/2008 | Winston-Salem St | 35 | @ | Hampton | 30 | MEAC | |||
| 11/8/2008 | Winston-Salem St | 27 | @ | Delaware St | 26 | MEAC | |||
| 11/15/2008 | Winston-Salem St | 16 | @ | North Carolina Central | 23 | ||||
| 11/22/2008 | Norfolk St | 17 | @ | Winston-Salem St | 14 | MEAC |