| 8/30/2008 | Western Illinois | 24 | @ | Arkansas | 28 | ||||
| 9/6/2008 | Quincy NAIA | 0 | @ | Western Illinois | 63 | ||||
| 9/13/2008 | Western Illinois | 22 | @ | S Dakota St | 24 | MVC | |||
| 9/20/2008 | SF Austin | 14 | @ | Western Illinois | 34 | ||||
| 10/4/2008 | Western Illinois | 33 | @ | Missouri State | 21 | MVC | |||
| 10/11/2008 | Western Illinois | 27 | @ | N Dakota St | 22 | ||||
| 10/18/2008 | Indiana St | 0 | @ | Western Illinois | 56 | MVC | |||
| 11/1/2008 | Northern Iowa | 30 | @ | Western Illinois | 6 | MVC | |||
| 11/8/2008 | Western Illinois | 14 | @ | Southern Illinois | 24 | MVC | |||
| 11/15/2008 | Illinois St | 45 | @ | Western Illinois | 48 | OT | MVC | ||
| 11/22/2008 | Youngstown St | 31 | @ | Western Illinois | 28 | MVC |