| 8/30/2008 | Michigan St | 31 | @ | California | 38 | ||||
| 9/6/2008 | Eastern Michigan | 10 | @ | Michigan St | 42 | ||||
| 9/13/2008 | Florida Atlantic | 0 | @ | Michigan St | 17 | ||||
| 9/20/2008 | Notre Dame | 7 | @ | Michigan St | 23 | ||||
| 9/27/2008 | Michigan St | 42 | @ | Indiana | 29 | B10 | |||
| 10/4/2008 | Iowa | 13 | @ | Michigan St | 16 | B10 | |||
| 10/11/2008 | Michigan St | 37 | @ | Northwestern | 20 | B10 | |||
| 10/18/2008 | Ohio State | 45 | @ | Michigan St | 7 | B10 | |||
| 10/25/2008 | Michigan St | 35 | @ | Michigan | 21 | B10 | |||
| 11/1/2008 | Wisconsin | 24 | @ | Michigan St | 25 | B10 | |||
| 11/8/2008 | Purdue | 7 | @ | Michigan St | 21 | B10 | |||
| 11/22/2008 | Michigan St | 18 | @ | Penn State | 49 | B10 | |||
| 1/1/2009 | Georgia | 24 | vs | Michigan St | 12 | Cap One (Orlando) |