| 8/28/2008 | Eastern Kentucky | 7 | @ | Cincinnati | 40 | ||||
| 9/6/2008 | Western Kentucky | 37 | @ | Eastern Kentucky | 13 | ||||
| 9/13/2008 | Morehead St | 8 | @ | Eastern Kentucky | 16 | ||||
| 9/20/2008 | Eastern Kentucky | 20 | @ | Tennessee St | 34 | OVC | |||
| 9/27/2008 | Austin Peay | 10 | @ | Eastern Kentucky | 13 | OVC | |||
| 10/4/2008 | Eastern Kentucky | 33 | @ | Tennessee Tech | 12 | OVC | |||
| 10/11/2008 | Jacksonville St | 35 | @ | Eastern Kentucky | 38 | OVC | |||
| 10/25/2008 | Eastern Illinois | 7 | @ | Eastern Kentucky | 20 | OVC | |||
| 11/1/2008 | Eastern Kentucky | 29 | @ | SE Missouri St | 16 | OVC | |||
| 11/15/2008 | Murray St | 7 | @ | Eastern Kentucky | 34 | OVC | |||
| 11/22/2008 | Eastern Kentucky | 33 | @ | Tennessee-Martin | 31 | OVC | |||
| 11/29/2008 | Eastern Kentucky | 10 | @ | Richmond | 38 | FCS championship round 1 |