| 8/30/2008 | Illinois St | 10 | @ | Marshall | 35 | ||||
| 9/13/2008 | Illinois St | 42 | @ | Murray St | 13 | ||||
| 9/20/2008 | Eastern Illinois | 25 | @ | Illinois St | 21 | ||||
| 10/4/2008 | Illinois St | 57 | @ | Indiana St | 6 | MVC | |||
| 10/11/2008 | Illinois St | 17 | @ | Northern Iowa | 31 | MVC | |||
| 10/18/2008 | Missouri State | 34 | @ | Illinois St | 28 | MVC | |||
| 10/25/2008 | N Dakota St | 25 | @ | Illinois St | 7 | ||||
| 11/1/2008 | Youngstown St | 44 | @ | Illinois St | 54 | MVC | |||
| 11/8/2008 | Illinois St | 21 | @ | S Dakota St | 52 | MVC | |||
| 11/15/2008 | Illinois St | 45 | @ | Western Illinois | 48 | OT | MVC | ||
| 11/22/2008 | Southern Illinois | 17 | @ | Illinois St | 10 | OT | MVC |