| 8/28/2008 | S Dakota St | 17 | @ | Iowa State | 44 | ||||
| 9/6/2008 | Youngstown St | 7 | @ | S Dakota St | 40 | MVC | |||
| 9/13/2008 | Western Illinois | 22 | @ | S Dakota St | 24 | MVC | |||
| 9/20/2008 | S Dakota St | 20 | @ | Northern Iowa | 34 | MVC | |||
| 9/27/2008 | S Dakota St | 50 | @ | SF Austin | 48 | ||||
| 10/4/2008 | McNeese St | 46 | @ | S Dakota St | 44 | 2 OT | |||
| 10/18/2008 | Cal Poly | 42 | @ | S Dakota St | 28 | ||||
| 10/25/2008 | S Dakota St | 49 | @ | Indiana St | 9 | MVC | |||
| 11/1/2008 | Missouri State | 13 | @ | S Dakota St | 43 | MVC | |||
| 11/8/2008 | Illinois St | 21 | @ | S Dakota St | 52 | MVC | |||
| 11/15/2008 | S Dakota St | 35 | @ | Southern Illinois | 38 | MVC | |||
| 11/22/2008 | S Dakota St | 25 | @ | N Dakota St | 24 |