| 8/30/2008 | Southern Univ | 3 | @ | Houston | 55 | ||||
| 9/6/2008 | Southern Univ | 32 | @ | Tennessee St | 34 | ||||
| 9/13/2008 | MS Valley St | 7 | @ | Southern Univ | 49 | SWAC | |||
| 9/27/2008 | Southern Univ | 15 | @ | Alcorn St | 12 | SWAC | |||
| 10/4/2008 | Southern Univ | 35 | @ | Jackson St | 28 | SWAC | |||
| 10/11/2008 | Texas Southern | 14 | @ | Southern Univ | 45 | SWAC | |||
| 10/18/2008 | Florida A&M | 52 | @ | Southern Univ | 49 | ||||
| 10/25/2008 | Southern Univ | 23 | vs | Prairie View | 24 | SWAC | Houston TX | ||
| 11/1/2008 | Ark Pine Bluff | 24 | @ | Southern Univ | 31 | OT | SWAC | ||
| 11/15/2008 | Southern Univ | 15 | vs | Alabama St | 0 | SWAC | Mobile AL | ||
| 11/29/2008 | Grambling | 29 | vs | Southern Univ | 14 | SWAC | New Orleans LA |