| 8/28/2008 | UTEP | 17 | @ | Buffalo | 42 | ||||
| 9/6/2008 | Buffalo | 16 | @ | Pittsburgh | 27 | ||||
| 9/13/2008 | Temple | 28 | @ | Buffalo | 30 | MAC | |||
| 9/20/2008 | Buffalo | 21 | @ | Missouri | 42 | ||||
| 9/27/2008 | Buffalo | 25 | @ | Central Michigan | 27 | MAC | |||
| 10/11/2008 | Western Michigan | 34 | @ | Buffalo | 28 | OT | MAC | ||
| 10/18/2008 | Army | 24 | @ | Buffalo | 27 | OT | |||
| 10/28/2008 | Buffalo | 32 | @ | Ohio | 19 | MAC | |||
| 11/4/2008 | Miami-Ohio | 17 | @ | Buffalo | 37 | MAC | |||
| 11/13/2008 | Buffalo | 43 | @ | Akron | 40 | 4 OT | MAC | ||
| 11/21/2008 | Buffalo | 40 | @ | Bowling Green | 34 | 2 OT | MAC | ||
| 11/28/2008 | Kent St | 24 | @ | Buffalo | 21 | MAC | |||
| 12/5/2008 | Ball State | 24 | vs | Buffalo | 42 | MAC | MAC Championship | ||
| 1/3/2009 | Buffalo | 20 | vs | Connecticut | 38 | International (Toronto) |