| 8/28/2008 | Upper Iowa D2 | 13 | @ | Drake | 17 | ||||
| 9/6/2008 | Drake | 0 | @ | Lehigh | 19 | ||||
| 9/13/2008 | William Penn NAIA | 0 | @ | Drake | 36 | ||||
| 9/27/2008 | San Diego | 43 | @ | Drake | 17 | Pio | |||
| 10/4/2008 | Drake | 15 | @ | Butler | 21 | Pio | |||
| 10/11/2008 | Drake | 9 | @ | Dayton | 27 | Pio | |||
| 10/18/2008 | Campbell | 0 | @ | Drake | 45 | Pio | |||
| 10/25/2008 | Davidson | 17 | @ | Drake | 20 | Pio | |||
| 11/8/2008 | Morehead St | 15 | @ | Drake | 19 | Pio | |||
| 11/15/2008 | Drake | 9 | @ | Jacksonville | 41 | Pio | |||
| 11/22/2008 | Drake | 32 | @ | Valparaiso | 0 | Pio |