| 8/28/2008 | Indiana St | 0 | @ | Eastern Michigan | 52 | ||||
| 9/6/2008 | Eastern Michigan | 10 | @ | Michigan St | 42 | ||||
| 9/13/2008 | Toledo | 41 | @ | Eastern Michigan | 17 | MAC | |||
| 9/20/2008 | Eastern Michigan | 24 | @ | Maryland | 51 | ||||
| 9/27/2008 | Northern Illinois | 37 | @ | Eastern Michigan | 0 | MAC | |||
| 10/4/2008 | Eastern Michigan | 24 | @ | Bowling Green | 21 | MAC | |||
| 10/11/2008 | Eastern Michigan | 13 | @ | Army | 17 | ||||
| 10/18/2008 | Akron | 42 | @ | Eastern Michigan | 35 | MAC | |||
| 10/25/2008 | Eastern Michigan | 16 | @ | Ball State | 38 | MAC | |||
| 11/1/2008 | Eastern Michigan | 10 | @ | Western Michigan | 31 | MAC | |||
| 11/22/2008 | Eastern Michigan | 52 | @ | Temple | 55 | MAC | |||
| 11/28/2008 | Central Michigan | 52 | @ | Eastern Michigan | 56 | MAC |