| 9/6/2008 | Hampton | 31 | @ | Southern Illinois | 37 | ||||
| 9/13/2008 | Southern Illinois | 7 | @ | Northwestern | 33 | ||||
| 9/27/2008 | Northern Iowa | 24 | @ | Southern Illinois | 27 | MVC | |||
| 10/4/2008 | Southern Illinois | 27 | @ | N Dakota St | 35 | ||||
| 10/11/2008 | Indiana St | 7 | @ | Southern Illinois | 60 | MVC | |||
| 10/18/2008 | Southern Illinois | 33 | @ | Youngstown St | 0 | MVC | |||
| 10/25/2008 | Southern Illinois | 23 | @ | Missouri State | 17 | OT | MVC | ||
| 11/1/2008 | North Dakota D2 | 21 | @ | Southern Illinois | 40 | ||||
| 11/8/2008 | Western Illinois | 14 | @ | Southern Illinois | 24 | MVC | |||
| 11/15/2008 | S Dakota St | 35 | @ | Southern Illinois | 38 | MVC | |||
| 11/22/2008 | Southern Illinois | 17 | @ | Illinois St | 10 | OT | MVC | ||
| 11/29/2008 | New Hampshire | 29 | @ | Southern Illinois | 20 | FCS championship round 1 |