| 8/30/2008 | Prairie View | 34 | @ | Texas Southern | 14 | SWAC | |||
| 9/6/2008 | Texas Southern | 10 | @ | Arkansas St | 83 | ||||
| 9/13/2008 | Shaw D2 | 29 | vs | Texas Southern | 40 | ||||
| 9/20/2008 | Texas Southern | 28 | @ | Texas College NAIA | 13 | ||||
| 9/27/2008 | Concordia AL NAIA | 27 | @ | Texas Southern | 45 | ||||
| 10/4/2008 | Texas Southern | 39 | @ | Texas St | 63 | ||||
| 10/11/2008 | Texas Southern | 14 | @ | Southern Univ | 45 | SWAC | |||
| 10/18/2008 | Jackson St | 30 | @ | Texas Southern | 14 | SWAC | |||
| 10/25/2008 | Texas Southern | 30 | @ | Alcorn St | 29 | SWAC | |||
| 11/8/2008 | MS Valley St | 58 | @ | Texas Southern | 44 | SWAC | |||
| 11/20/2008 | Grambling | 33 | @ | Texas Southern | 7 | SWAC | |||
| 11/29/2008 | Texas Southern | 7 | @ | Ark Pine Bluff | 28 | SWAC |