| 8/31/2008 | Kentucky | 27 | @ | Louisville | 2 | ||||
| 9/6/2008 | Tennessee Tech | 10 | @ | Louisville | 51 | ||||
| 9/17/2008 | Kansas St | 29 | @ | Louisville | 38 | ||||
| 9/26/2008 | Connecticut | 26 | @ | Louisville | 21 | BigE | |||
| 10/10/2008 | Louisville | 35 | @ | Memphis | 28 | ||||
| 10/18/2008 | Middle Tenn St | 23 | @ | Louisville | 42 | ||||
| 10/25/2008 | South Florida | 20 | @ | Louisville | 24 | BigE | |||
| 11/1/2008 | Louisville | 21 | @ | Syracuse | 28 | BigE | |||
| 11/8/2008 | Louisville | 7 | @ | Pittsburgh | 41 | BigE | |||
| 11/14/2008 | Cincinnati | 28 | @ | Louisville | 20 | BigE | |||
| 11/22/2008 | West Virginia | 35 | @ | Louisville | 21 | BigE | |||
| 12/4/2008 | Louisville | 14 | @ | Rutgers | 63 | BigE |