| 8/30/2008 | Virginia Tech | 22 | vs | East Carolina | 27 | ||||
| 9/6/2008 | West Virginia | 3 | @ | East Carolina | 24 | ||||
| 9/13/2008 | East Carolina | 28 | @ | Tulane | 24 | CUSA | |||
| 9/20/2008 | East Carolina | 24 | @ | North Carolina St | 30 | OT | |||
| 9/27/2008 | Houston | 41 | @ | East Carolina | 24 | CUSA | |||
| 10/11/2008 | East Carolina | 20 | @ | Virginia | 35 | ||||
| 10/18/2008 | Memphis | 10 | @ | East Carolina | 30 | CUSA | |||
| 11/2/2008 | East Carolina | 13 | @ | UCF | 10 | OT | CUSA | ||
| 11/8/2008 | Marshall | 16 | @ | East Carolina | 19 | OT | CUSA | ||
| 11/15/2008 | East Carolina | 3 | @ | Southern Miss | 21 | CUSA | |||
| 11/22/2008 | East Carolina | 17 | @ | UAB | 13 | CUSA | |||
| 11/28/2008 | UTEP | 21 | @ | East Carolina | 53 | CUSA | |||
| 12/6/2008 | East Carolina | 27 | @ | Tulsa | 24 | CUSA | CUSA Championship | ||
| 1/2/2009 | Kentucky | 25 | vs | East Carolina | 19 | Liberty (Memphis) |