| 8/30/2008 | Western Kentucky | 13 | @ | Indiana | 31 | ||||
| 9/6/2008 | Western Kentucky | 37 | @ | Eastern Kentucky | 13 | ||||
| 9/13/2008 | Western Kentucky | 7 | @ | Alabama | 41 | ||||
| 9/20/2008 | Murray St | 9 | @ | Western Kentucky | 50 | ||||
| 9/27/2008 | Western Kentucky | 3 | @ | Kentucky | 41 | ||||
| 10/4/2008 | Western Kentucky | 13 | @ | Virginia Tech | 27 | ||||
| 10/11/2008 | Ball State | 24 | @ | Western Kentucky | 7 | ||||
| 10/18/2008 | Florida Atlantic | 24 | @ | Western Kentucky | 20 | ||||
| 11/1/2008 | North Texas | 51 | @ | Western Kentucky | 40 | ||||
| 11/8/2008 | Western Kentucky | 7 | @ | Troy | 17 | ||||
| 11/15/2008 | Middle Tenn St | 21 | @ | Western Kentucky | 10 | ||||
| 12/6/2008 | Western Kentucky | 3 | @ | Florida Intl | 27 |