| 8/30/2008 | Illinois | 42 | @ | Missouri | 52 | ||||
| 9/6/2008 | SE Missouri St | 3 | @ | Missouri | 52 | ||||
| 9/13/2008 | Nevada | 17 | @ | Missouri | 69 | ||||
| 9/20/2008 | Buffalo | 21 | @ | Missouri | 42 | ||||
| 10/4/2008 | Missouri | 52 | @ | Nebraska | 17 | B12 | |||
| 10/11/2008 | Oklahoma St | 28 | @ | Missouri | 23 | B12 | |||
| 10/18/2008 | Missouri | 31 | @ | Texas | 56 | B12 | |||
| 10/25/2008 | Colorado | 0 | @ | Missouri | 58 | B12 | |||
| 11/1/2008 | Missouri | 31 | @ | Baylor | 28 | B12 | |||
| 11/8/2008 | Kansas St | 24 | @ | Missouri | 41 | B12 | |||
| 11/15/2008 | Missouri | 52 | @ | Iowa State | 20 | B12 | |||
| 11/29/2008 | Kansas | 40 | vs | Missouri | 37 | B12 | Kansas City MO | ||
| 12/6/2008 | Missouri | 21 | vs | Oklahoma | 62 | B12 | Big 12 Championship | ||
| 12/29/2008 | Northwestern | 23 | vs | Missouri | 30 | OT | Alamo (San Antonio) |