| 9/1/2022 | Lamar | 14 | at | Abilene Christian | 28 | @ WAC | ||
| Lincoln CA | 7 | at | Texas A&M-Commerce | 52 | None (Unk?) | |||
| 9/3/2022 | Southern Illinois | 29 | at | Incarnate Word | 64 | MVC | ||
| Southeastern Louisiana | 7 | at | UL Lafayette | 24 | @ SBC (1A) | |||
| Northwestern State | 0 | at | Montana | 47 | @ BSky | |||
| McNeese State | 17 | at | Montana State | 40 | @ BSky | |||
| Houston Christian | 46 | at | Northern Colorado | 34 | @ BSky | |||
| Nicholls State | 7 | at | South Alabama | 48 | @ SBC (1A) | |||
| 9/10/2022 | Southeastern Louisiana | 9 | at | Florida Atlantic | 42 | @ CUSA (1A) | ||
| Northwestern State | 21 | vs | Grambling | 47 | Shreveport LA | vs SWAC | ||
| Lindenwood | 21 | at | Houston Christian | 20 | OVC | |||
| Nicholls State | 7 | at | UL Monroe | 35 | @ SBC (1A) | |||
| Incarnate Word | 55 | at | Nevada | 41 | @ MW (1A) | |||
| McNeese State | 10 | at | Rice | 52 | @ CUSA (1A) | |||
| Lamar | 16 | at | SMU | 45 | @ AAC (1A) | |||
| Texas A&M-Commerce | 25 | at | Tennessee Tech | 26 | @ OVC | |||
| 9/17/2022 | Northern Colorado | 21 | at | Lamar | 14 | BSky | ||
| Alcorn State | 30 | at | McNeese State | 19 | SWAC | |||
| Incarnate Word | 31 | at | Prairie View | 14 | @ SWAC | |||
| Texas A&M-Commerce | 17 | at | Sam Houston | 27 | @ WAC | |||
| Central Conn | 6 | at | Southeastern Louisiana | 70 | NE | |||
| Nicholls State | 16 | at | SE Missouri State | 42 | @ OVC | |||
| Northwestern State | 10 | at | Southern Miss | 64 | @ SBC (1A) | |||
| 9/24/2022 | Mississippi College | 17 | at | McNeese State | 32 | GSC (D2) | ||
| Jacksonville State | 52 | at | Nicholls State | 21 | ASUN | |||
| Lamar | 27 | at | Northwestern State | 35 | ||||
| Incarnate Word | 35 | at | Southeastern Louisiana | 41 | ||||
| North American U | 3 | at | Texas A&M-Commerce | 63 | None (Unk?) | |||
| Houston Christian | 0 | at | Texas State | 34 | @ SBC (1A) | |||
| 10/1/2022 | McNeese State | 20 | at | Incarnate Word | 48 | |||
| Houston Christian | 37 | at | Lamar | 34 | ||||
| Nicholls State | 33 | at | Northwestern State | 36 | ||||
| Murray State | 14 | at | Southeastern Louisiana | 48 | OVC | |||
| 10/8/2022 | Northwestern State | 27 | at | Eastern Illinois | 35 | @ OVC | ||
| Nicholls State | 19 | at | Houston Christian | 17 | ||||
| Lamar | 17 | at | Incarnate Word | 56 | ||||
| Texas A&M-Commerce | 31 | at | Southeastern Louisiana | 28 | ||||
| 10/15/2022 | Northwestern State | 37 | at | Houston Christian | 10 | |||
| Texas A&M-Commerce | 40 | at | McNeese State | 15 | ||||
| Incarnate Word | 49 | at | Nicholls State | 14 | ||||
| 10/22/2022 | Faulkner | 0 | at | Incarnate Word | 70 | MSC (NAIA) | ||
| Southeastern Louisiana | 31 | at | Jacksonville State | 14 | @ ASUN | |||
| Prairie View | 54 | at | Lamar | 21 | SWAC | |||
| McNeese State | 35 | at | Nicholls State | 40 | ||||
| SE Missouri State | 51 | at | Northwestern State | 16 | OVC | |||
| Houston Christian | 3 | at | Texas A&M-Commerce | 31 | ||||
| 10/29/2022 | Tennessee-Martin | 52 | at | Houston Christian | 28 | OVC | ||
| Nicholls State | 17 | at | Lamar | 24 | ||||
| Southeastern Louisiana | 28 | at | McNeese State | 27 | ||||
| Incarnate Word | 35 | at | Texas A&M-Commerce | 7 | ||||
| 11/5/2022 | Houston Christian | 20 | at | Incarnate Word | 73 | |||
| Southeastern Louisiana | 47 | at | Lamar | 31 | ||||
| Eastern Illinois | 15 | at | McNeese State | 29 | OVC | |||
| Northwestern State | 41 | at | Texas A&M-Commerce | 14 | ||||
| 11/12/2022 | McNeese State | 21 | at | Houston Christian | 10 | |||
| Lamar | 14 | at | New Mexico State | 51 | @ Ind (1A) | |||
| Texas A&M-Commerce | 10 | at | Nicholls State | 12 | ||||
| Northwestern State | 7 | at | Southeastern Louisiana | 23 | ||||
| 11/17/2022 | Southeastern Louisiana | 40 | at | Nicholls State | 17 | |||
| 11/19/2022 | Lamar | 20 | at | McNeese State | 24 | |||
| Incarnate Word | 66 | at | Northwestern State | 7 | ||||
| Tennessee State | 22 | at | Texas A&M-Commerce | 14 | OVC | |||
| Houston Christian | 7 | at | Tarleton State | 49 | @ WAC | |||
| 11/26/2022 | Idaho | 42 | at | Southeastern Louisiana | 45 | FCS Championship - Round 1 | BSky | |
| 12/3/2022 | Furman | 38 | at | Incarnate Word | 41 | FCS Playoffs Round 2 | SoCon | |
| Southeastern Louisiana | 42 | at | Samford | 48 | OT | FCS Playoffs Round 2 | @ SoCon | |
| 12/9/2022 | Incarnate Word | 66 | at | Sacramento State | 63 | FCS Quarterful | @ BSky | |
| 12/16/2022 | Incarnate Word | 32 | at | North Dakota State | 35 | FCS Semifinal | @ MVC |