| 9/3/2022 | Murray State | 10 | at | Texas Tech (8-5) | 63 | at B12 | ||
| 9/10/2022 | Jacksonville State (9-2) | 34 | at | Murray State | 3 | ASUN | ||
| 9/17/2022 | Murray State | 0 | at | Ball State (5-7) | 31 | at MAC | ||
| 9/24/2022 | Eastern Illinois (2-9,1-5) | 35 | at | Murray State | 21 | |||
| 10/1/2022 | Murray State | 14 | at | Southeastern Louisiana (9-4) | 48 | at SLC | ||
| 10/8/2022 | Tennessee-Martin (7-4,5-0) | 45 | at | Murray State | 16 | |||
| 10/15/2022 | Murray State | 17 | at | Austin Peay (7-4) | 52 | at ASUN | ||
| 10/22/2022 | Murray State | 18 | at | Lindenwood (7-3,2-3) | 33 | |||
| 10/29/2022 | Tennessee State (4-7,2-3) | 3 | at | Murray State | 19 | |||
| 11/12/2022 | Robert Morris (0-11) | 9 | at | Murray State | 27 | BigS | ||
| 11/19/2022 | Murray State | 22 | at | SE Missouri State (9-3,5-0) | 52 |
| vs Murray State | vs Other Opponents | Murray State compared to OOs | |
| Record: | 9-2 | 58-57 | |
| Points Scored: | 36.82 | 28.54 | -8.28 |
| Points Allowed: | 15.18 | 28.62 | -13.44 |
| Margin: | 21.64 | -0.08 | -21.72 |
| Total Points: | 52.00 | 57.16 | -5.16 |