| 9/3/2022 | Drake (3-8) | 14 | at | North Dakota State | 56 | Pio | ||
| 9/10/2022 | North Carolina A&T (7-4) | 3 | at | North Dakota State | 43 | BigS | ||
| 9/17/2022 | North Dakota State | 28 | at | Arizona (5-7) | 31 | at P12 | ||
| 9/24/2022 | North Dakota State | 34 | at | South Dakota (3-8,2-6) | 17 | |||
| 10/1/2022 | Youngstown State (7-4,5-3) | 14 | at | North Dakota State | 27 | |||
| 10/8/2022 | North Dakota State | 31 | at | Indiana State (2-9,1-7) | 26 | |||
| 10/15/2022 | South Dakota State (14-1,9-0) | 23 | at | North Dakota State | 21 | |||
| 10/29/2022 | Illinois State (6-5,4-4) | 7 | at | North Dakota State | 24 | |||
| 11/5/2022 | North Dakota State | 56 | at | Western Illinois (0-11,0-8) | 17 | |||
| 11/12/2022 | North Dakota State | 21 | at | Southern Illinois (5-6,4-4) | 18 | |||
| 11/19/2022 | North Dakota (7-5,5-3) | 21 | at | North Dakota State | 42 | |||
| 12/3/2022 | Montana (8-5) | 26 | at | North Dakota State | 49 | FCS Playoffs Round 2 | BSky | |
| 12/9/2022 | Samford (11-2) | 9 | at | North Dakota State | 27 | FCS Quarterful | SoCon | |
| 12/16/2022 | Incarnate Word (12-2) | 32 | at | North Dakota State | 35 | FCS Semifinal | SLC | |
| 1/8/2023 | North Dakota State | 21 | vs | South Dakota State (14-1,9-0) | 45 | Frisco TX - FCS Championship |
| vs North Dakota State | vs Other Opponents | North Dakota State compared to OOs | |
| Record: | 3-12 | 99-66 | |
| Points Scored: | 20.20 | 29.72 | 9.52 |
| Points Allowed: | 34.33 | 25.61 | 8.72 |
| Margin: | -14.13 | 4.11 | 18.24 |
| Total Points: | 54.53 | 55.33 | -0.80 |