| 9/3/2022 | Rice | 14 | at | Southern California (11-3) | 66 | at P12 | ||
| 9/10/2022 | McNeese State (4-7) | 10 | at | Rice | 52 | SLC (1AA) | ||
| 9/17/2022 | UL Lafayette (6-7) | 21 | at | Rice | 33 | SBC | ||
| 9/24/2022 | Rice | 27 | at | Houston (8-5) | 34 | at AAC | ||
| 10/1/2022 | UAB (7-6,4-4) | 24 | at | Rice | 28 | |||
| 10/15/2022 | Rice | 14 | at | Florida Atlantic (5-7,4-4) | 17 | |||
| 10/22/2022 | Rice | 42 | at | Louisiana Tech (3-9,2-6) | 41 | OT | ||
| 10/29/2022 | UNC-Charlotte (3-9,2-6) | 56 | at | Rice | 23 | |||
| 11/3/2022 | UTEP (5-7,3-5) | 30 | at | Rice | 37 | |||
| 11/12/2022 | Rice | 10 | at | Western Kentucky (9-5,6-2) | 45 | |||
| 11/19/2022 | Texas-San Antonio (11-3,9-0) | 41 | at | Rice | 7 | |||
| 11/26/2022 | Rice | 17 | at | North Texas (7-7,6-3) | 21 | |||
| 12/17/2022 | Rice | 24 | vs | Southern Miss (7-6) | 38 | Mobile AL | vs SBC |
| vs Rice | vs Other Opponents | Rice compared to OOs | |
| Record: | 8-5 | 78-76 | |
| Points Scored: | 34.15 | 30.53 | -3.62 |
| Points Allowed: | 25.23 | 28.89 | -3.66 |
| Margin: | 8.92 | 1.64 | -7.28 |
| Total Points: | 59.38 | 59.42 | -0.04 |