| 9/3/2022 | Mississippi College | 14 | at | Albany State GA (7-3) | 28 | at SIAC | ||
| 9/10/2022 | Keiser (10-4) | 8 | at | Mississippi College | 26 | Sun (NAIA) | ||
| 9/17/2022 | North Greenville (3-8,2-6) | 41 | at | Mississippi College | 19 | |||
| 9/24/2022 | Mississippi College | 17 | at | McNeese State (4-7) | 32 | at SLC | ||
| 10/1/2022 | Mississippi College | 39 | at | West Georgia (8-2,6-2) | 38 | |||
| 10/8/2022 | Shorter (3-8,1-7) | 21 | at | Mississippi College | 35 | |||
| 10/15/2022 | Mississippi College | 49 | at | Valdosta State (5-6,3-5) | 40 | |||
| 10/22/2022 | Mississippi College | 17 | at | West Florida (12-2,8-1) | 45 | |||
| 10/29/2022 | Delta State (11-2,7-2) | 52 | at | Mississippi College | 38 | |||
| 11/5/2022 | Mississippi College | 16 | at | West Alabama (5-6,3-5) | 38 | |||
| 11/12/2022 | West Florida (12-2,8-1) | 56 | at | Mississippi College | 21 |
| vs Mississippi College | vs Other Opponents | Mississippi College compared to OOs | |
| Record: | 7-4 | 71-46 | |
| Points Scored: | 36.27 | 33.48 | -2.79 |
| Points Allowed: | 26.45 | 26.54 | -0.09 |
| Margin: | 9.82 | 6.94 | -2.88 |
| Total Points: | 62.72 | 60.02 | 2.70 |