| 9/3/2022 | Texas Southern (5-6,4-4) | 23 | at | Prairie View | 40 | |||
| 9/10/2022 | Prairie View | 13 | at | Abilene Christian (7-4) | 21 | at WAC | ||
| 9/17/2022 | Incarnate Word (12-2) | 31 | at | Prairie View | 14 | SLC | ||
| 9/24/2022 | Prairie View | 24 | at | Alabama State (6-5,4-4) | 15 | |||
| 10/1/2022 | Prairie View | 34 | vs | Grambling (3-8,2-7) | 14 | Dallas TX | ||
| 10/8/2022 | Southern (7-5,5-4) | 45 | at | Prairie View | 13 | |||
| 10/22/2022 | Prairie View | 54 | at | Lamar (1-10) | 21 | at SLC | ||
| 10/29/2022 | Bethune-Cookman (2-9,2-6) | 48 | at | Prairie View | 58 | |||
| 11/4/2022 | Alcorn State (5-6,4-4) | 23 | at | Prairie View | 16 | OT | ||
| 11/12/2022 | Prairie View | 55 | at | Ark Pine Bluff (3-8,1-7) | 24 | |||
| 11/19/2022 | Prairie View | 7 | at | Mississippi Valley State (2-9,2-6) | 27 |
| vs Prairie View | vs Other Opponents | Prairie View compared to OOs | |
| Record: | 5-6 | 48-66 | |
| Points Scored: | 26.55 | 26.28 | -0.27 |
| Points Allowed: | 29.82 | 28.48 | 1.34 |
| Margin: | -3.27 | -2.20 | 1.07 |
| Total Points: | 56.37 | 54.76 | 1.61 |