| 9/3/2022 | Stephen F. Austin (6-5) | 31 | at | Alcorn State | 27 | WAC | ||
| 9/10/2022 | Alcorn State | 0 | at | Tulane (12-2) | 52 | at AAC | ||
| 9/17/2022 | Alcorn State | 30 | at | McNeese State (4-7) | 19 | at SLC | ||
| 9/24/2022 | Ark Pine Bluff (3-8,1-7) | 21 | at | Alcorn State | 38 | |||
| 10/8/2022 | Alcorn State | 30 | at | Mississippi Valley State (2-9,2-6) | 7 | |||
| 10/15/2022 | Alcorn State | 17 | at | Southern (7-5,5-4) | 21 | |||
| 10/22/2022 | Texas Southern (5-6,4-4) | 34 | at | Alcorn State | 27 | |||
| 10/29/2022 | Alcorn State | 6 | at | Grambling (3-8,2-7) | 35 | |||
| 11/4/2022 | Alcorn State | 23 | at | Prairie View (6-5,5-3) | 16 | OT | ||
| 11/12/2022 | Bethune-Cookman (2-9,2-6) | 14 | at | Alcorn State | 17 | |||
| 11/19/2022 | Jackson State (12-1,10-0) | 24 | at | Alcorn State | 13 |
| vs Alcorn State | vs Other Opponents | Alcorn State compared to OOs | |
| Record: | 6-5 | 56-60 | |
| Points Scored: | 24.91 | 28.14 | 3.23 |
| Points Allowed: | 20.73 | 28.47 | -7.74 |
| Margin: | 4.18 | -0.33 | -4.51 |
| Total Points: | 45.64 | 56.61 | -10.97 |