| 9/3/2022 | Sam Houston | 0 | at | Texas A&M (5-7) | 31 | at SEC | ||
| 9/10/2022 | Northern Arizona (3-8) | 10 | at | Sam Houston | 3 | BSky | ||
| 9/17/2022 | Texas A&M-Commerce (5-6) | 17 | at | Sam Houston | 27 | SLC | ||
| 10/1/2022 | Stephen F. Austin (6-5,4-2) | 16 | vs | Sam Houston | 17 | Houston TX | ||
| 10/15/2022 | Sam Houston | 25 | at | Eastern Kentucky (7-5) | 17 | at ASUN | ||
| 10/22/2022 | Sam Houston | 18 | at | Utah Tech (4-7,3-3) | 13 | |||
| 10/29/2022 | Sam Houston | 40 | at | Tarleton State (6-5,1-4) | 21 | |||
| 11/12/2022 | Abilene Christian (7-4,4-2) | 45 | at | Sam Houston | 28 | |||
| 11/19/2022 | Southern Utah (5-6,2-4) | 17 | at | Sam Houston | 7 |
| vs Sam Houston | vs Other Opponents | Sam Houston compared to OOs | |
| Record: | 4-5 | 44-48 | |
| Points Scored: | 20.78 | 29.78 | 9.00 |
| Points Allowed: | 18.33 | 28.66 | -10.33 |
| Margin: | 2.45 | 1.12 | -1.33 |
| Total Points: | 39.11 | 58.44 | -19.33 |