| 9/1/2022 | Mississippi Valley State (2-9) | 13 | at | Tarleton State | 29 | SWAC | ||
| 9/10/2022 | Tarleton State | 17 | at | TCU (13-2) | 59 | at B12 | ||
| 9/17/2022 | Eastern New Mexico (3-8) | 6 | at | Tarleton State | 41 | LSC (D2) | ||
| 9/24/2022 | Tarleton State | 43 | at | North Alabama (1-10) | 28 | at ASUN | ||
| 10/8/2022 | Tarleton State | 42 | at | Southern Utah (5-6,2-4) | 40 | |||
| 10/15/2022 | Tarleton State | 24 | at | Stephen F. Austin (6-5,4-2) | 41 | |||
| 10/22/2022 | Southwest Baptist (6-5) | 10 | at | Tarleton State | 24 | GLV (D2) | ||
| 10/29/2022 | Sam Houston (5-4,3-2) | 40 | at | Tarleton State | 21 | |||
| 11/5/2022 | Abilene Christian (7-4,4-2) | 28 | at | Tarleton State | 23 | |||
| 11/12/2022 | Tarleton State | 28 | at | Utah Tech (4-7,3-3) | 34 | |||
| 11/19/2022 | Houston Christian (2-9) | 7 | at | Tarleton State | 49 | SLC |
| vs Tarleton State | vs Other Opponents | Tarleton State compared to OOs | |
| Record: | 5-6 | 49-63 | |
| Points Scored: | 27.82 | 26.73 | -1.09 |
| Points Allowed: | 31.00 | 30.69 | 0.31 |
| Margin: | -3.18 | -3.96 | -0.78 |
| Total Points: | 58.82 | 57.42 | 1.40 |