| 9/1/2022 | Western Illinois (0-11) | 25 | at | Tennessee-Martin | 42 | MVC | ||
| 9/8/2022 | Tennessee-Martin | 30 | at | Missouri State (5-6) | 35 | at MVC | ||
| 9/17/2022 | Tennessee-Martin | 7 | at | Boise State (10-4) | 30 | at MW | ||
| 9/24/2022 | Lindenwood (7-3,2-3) | 26 | at | Tennessee-Martin | 56 | |||
| 10/1/2022 | Tennessee Tech (4-7,2-3) | 28 | at | Tennessee-Martin | 45 | |||
| 10/8/2022 | Tennessee-Martin | 45 | at | Murray State (2-9,1-4) | 16 | |||
| 10/22/2022 | Tennessee-Martin | 24 | at | Tennessee (11-2) | 65 | at SEC | ||
| 10/29/2022 | Tennessee-Martin | 52 | at | Houston Christian (2-9) | 28 | at SLC | ||
| 11/5/2022 | Kennesaw St (5-6) | 44 | at | Tennessee-Martin | 27 | ASUN | ||
| 11/12/2022 | Tennessee-Martin | 20 | at | Tennessee State (4-7,2-3) | 3 | |||
| 11/19/2022 | Eastern Illinois (2-9,1-5) | 31 | at | Tennessee-Martin | 34 |
| vs Tennessee-Martin | vs Other Opponents | Tennessee-Martin compared to OOs | |
| Record: | 4-7 | 48-66 | |
| Points Scored: | 30.09 | 25.49 | -4.60 |
| Points Allowed: | 34.73 | 29.83 | 4.90 |
| Margin: | -4.64 | -4.34 | 0.30 |
| Total Points: | 64.82 | 55.32 | 9.50 |