| 9/3/2022 | SE Missouri State | 10 | at | Iowa State (4-8) | 42 | at B12 | ||
| 9/10/2022 | SE Missouri State | 34 | at | Southern Illinois (5-6) | 31 | at MVC | ||
| 9/17/2022 | Nicholls State (3-8) | 16 | at | SE Missouri State | 42 | SLC | ||
| 9/24/2022 | Central Arkansas (5-6) | 27 | at | SE Missouri State | 35 | ASUN | ||
| 10/1/2022 | SE Missouri State | 49 | at | Lindenwood (7-3,2-3) | 28 | |||
| 10/8/2022 | Tennessee Tech (4-7,2-3) | 20 | at | SE Missouri State | 34 | |||
| 10/22/2022 | SE Missouri State | 51 | at | Northwestern State (4-7) | 16 | at SLC | ||
| 10/29/2022 | Eastern Kentucky (7-5) | 28 | at | SE Missouri State | 23 | ASUN | ||
| 11/5/2022 | SE Missouri State | 42 | at | Tennessee State (4-7,2-3) | 0 | |||
| 11/12/2022 | SE Missouri State | 31 | at | Eastern Illinois (2-9,1-5) | 7 | |||
| 11/19/2022 | Murray State (2-9,1-4) | 22 | at | SE Missouri State | 52 | |||
| 11/26/2022 | SE Missouri State | 24 | at | Montana (8-5) | 34 | FCS Championship - Round 1 | at BSky |
| vs SE Missouri State | vs Other Opponents | SE Missouri State compared to OOs | |
| Record: | 3-9 | 52-71 | |
| Points Scored: | 22.58 | 26.45 | 3.87 |
| Points Allowed: | 35.58 | 29.78 | 5.80 |
| Margin: | -13.00 | -3.33 | 9.67 |
| Total Points: | 58.16 | 56.23 | 1.93 |