| 9/2/2022 | Tennessee Tech | 10 | at | Kansas (6-7) | 56 | at B12 | ||
| 9/10/2022 | Texas A&M-Commerce (5-6) | 25 | at | Tennessee Tech | 26 | SLC | ||
| 9/17/2022 | Samford (11-2) | 33 | at | Tennessee Tech | 28 | SoCon | ||
| 10/1/2022 | Tennessee Tech | 28 | at | Tennessee-Martin (7-4,5-0) | 45 | |||
| 10/8/2022 | Tennessee Tech | 20 | at | SE Missouri State (9-3,5-0) | 34 | |||
| 10/15/2022 | Tennessee State (4-7,2-3) | 30 | at | Tennessee Tech | 14 | |||
| 10/22/2022 | Tennessee Tech | 30 | at | Kennesaw St (5-6) | 33 | OT | at ASUN | |
| 10/29/2022 | Tennessee Tech | 20 | at | Eastern Illinois (2-9,1-5) | 17 | |||
| 11/5/2022 | Lindenwood (7-3,2-3) | 34 | at | Tennessee Tech | 35 | |||
| 11/12/2022 | Tennessee Tech | 35 | at | North Alabama (1-10) | 27 | at ASUN | ||
| 11/19/2022 | North Carolina Central (10-2) | 22 | at | Tennessee Tech | 20 | MEAC |
| vs Tennessee Tech | vs Other Opponents | Tennessee Tech compared to OOs | |
| Record: | 7-4 | 60-55 | |
| Points Scored: | 32.36 | 31.01 | -1.35 |
| Points Allowed: | 24.18 | 29.43 | -5.25 |
| Margin: | 8.18 | 1.58 | -6.60 |
| Total Points: | 56.54 | 60.44 | -3.90 |