| 9/3/2022 | Grambling | 3 | at | Arkansas State (3-9) | 58 | at SBC | ||
| 9/10/2022 | Northwestern State (4-7) | 21 | vs | Grambling | 47 | Shreveport LA | SLC | |
| 9/17/2022 | Grambling | 24 | at | Jackson State (12-1,10-0) | 66 | |||
| 9/24/2022 | Grambling | 19 | at | Bethune-Cookman (2-9,2-6) | 36 | |||
| 10/1/2022 | Prairie View (6-5,5-3) | 34 | vs | Grambling | 14 | Dallas TX | ||
| 10/8/2022 | Grambling | 31 | at | Alabama A&M (4-7,4-4) | 37 | OT | ||
| 10/15/2022 | Florida A&M (9-2,7-1) | 20 | at | Grambling | 16 | |||
| 10/29/2022 | Alcorn State (5-6,4-4) | 6 | at | Grambling | 35 | |||
| 11/5/2022 | Ark Pine Bluff (3-8,1-7) | 10 | at | Grambling | 36 | |||
| 11/12/2022 | Grambling | 7 | at | Texas Southern (5-6,4-4) | 41 | |||
| 11/26/2022 | Grambling | 17 | vs | Southern (7-5,5-4) | 34 | New Orleans LA |
| vs Grambling | vs Other Opponents | Grambling compared to OOs | |
| Record: | 8-3 | 52-62 | |
| Points Scored: | 33.00 | 25.51 | -7.49 |
| Points Allowed: | 22.64 | 28.61 | -5.97 |
| Margin: | 10.36 | -3.10 | -13.46 |
| Total Points: | 55.64 | 54.12 | 1.52 |