| 8/27/2022 | Stephen F. Austin | 17 | vs | Jacksonville State | 42 | Montgomery AL | vs WAC | |
| Austin Peay | 27 | at | Western Kentucky | 38 | @ CUSA (1A) | |||
| 9/1/2022 | Missouri State | 27 | at | Central Arkansas | 14 | MVC | ||
| North Alabama | 14 | at | Indiana State | 17 | OT | @ MVC | ||
| Kennesaw St | 17 | at | Samford | 27 | @ SoCon | |||
| 9/2/2022 | Eastern Kentucky | 34 | at | Eastern Michigan | 42 | @ MAC (1A) | ||
| 9/3/2022 | Presbyterian | 0 | at | Austin Peay | 63 | Pio | ||
| Davidson | 17 | at | Jacksonville State | 35 | Pio | |||
| 9/10/2022 | Mississippi Valley State | 0 | at | Austin Peay | 41 | SWAC | ||
| Eastern Kentucky | 59 | at | Bowling Green | 57 | 7OT | @ MAC (1A) | ||
| Kennesaw St | 10 | at | Cincinnati | 63 | @ AAC (1A) | |||
| Central Arkansas | 3 | at | Mississippi | 59 | @ SEC (1A) | |||
| Jacksonville State | 34 | at | Murray State | 3 | @ OVC | |||
| Virginia-Wise | 17 | at | North Alabama | 49 | SAC (D2) | |||
| 9/17/2022 | Austin Peay | 28 | at | Alabama A&M | 3 | @ SWAC | ||
| North Alabama | 14 | at | Chattanooga | 41 | @ SoCon | |||
| Charleston Southern | 17 | at | Eastern Kentucky | 40 | BigS | |||
| Central Arkansas | 31 | at | Idaho State | 16 | @ BSky | |||
| Jacksonville State | 17 | at | Tulsa | 54 | @ AAC (1A) | |||
| 9/24/2022 | Eastern Kentucky | 20 | at | Austin Peay | 31 | |||
| Wofford | 22 | at | Kennesaw St | 24 | SoCon | |||
| Jacksonville State | 52 | at | Nicholls State | 21 | @ SLC | |||
| Tarleton State | 43 | at | North Alabama | 28 | WAC | |||
| Central Arkansas | 27 | at | SE Missouri State | 35 | @ OVC | |||
| 10/1/2022 | Austin Peay | 20 | at | Central Arkansas | 49 | |||
| Southern Utah | 28 | at | Eastern Kentucky | 35 | WAC | |||
| Kennesaw St | 28 | at | Jacksonville State | 35 | OT | |||
| 10/8/2022 | Lindenwood | 52 | at | Central Arkansas | 49 | OVC | ||
| North Alabama | 34 | at | Kennesaw St | 40 | 2OT | |||
| 10/15/2022 | Murray State | 17 | at | Austin Peay | 52 | OVC | ||
| Sam Houston | 25 | at | Eastern Kentucky | 17 | WAC | |||
| Central Arkansas | 51 | at | Kennesaw St | 24 | ||||
| Jacksonville State | 47 | vs | North Alabama | 31 | Madison AL | |||
| 10/22/2022 | North Alabama | 53 | at | Eastern Kentucky | 56 | |||
| Southeastern Louisiana | 31 | at | Jacksonville State | 14 | SLC | |||
| Tennessee Tech | 30 | at | Kennesaw St | 33 | OT | OVC | ||
| 10/29/2022 | Jacksonville State | 40 | at | Austin Peay | 16 | |||
| North Alabama | 29 | at | Central Arkansas | 64 | ||||
| Charleston Southern | 20 | at | Kennesaw St | 30 | BigS | |||
| Eastern Kentucky | 28 | at | SE Missouri State | 23 | @ OVC | |||
| 11/5/2022 | Central Arkansas | 14 | at | Eastern Kentucky | 42 | |||
| Austin Peay | 38 | at | North Alabama | 35 | ||||
| Kennesaw St | 44 | at | Tennessee-Martin | 27 | @ OVC | |||
| 11/12/2022 | Eastern Kentucky | 17 | at | Jacksonville State | 42 | |||
| Austin Peay | 31 | at | Kennesaw St | 14 | ||||
| Tennessee Tech | 35 | at | North Alabama | 27 | OVC | |||
| Central Arkansas | 34 | at | Stephen F. Austin | 7 | @ WAC | |||
| 11/19/2022 | Austin Peay | 0 | at | Alabama | 34 | @ SEC (1A) | ||
| Jacksonville State | 40 | at | Central Arkansas | 17 | ||||
| Kennesaw St | 38 | at | Eastern Kentucky | 45 | ||||
| North Alabama | 0 | at | Memphis | 59 | @ AAC (1A) | |||
| 11/26/2022 | Gardner-Webb | 52 | at | Eastern Kentucky | 41 | FCS Championship - Round 1 | BigS |