| 9/1/2022 | Ferrum (1-9) | 9 | at | Virginia-Wise | 41 | ODC (D3) | ||
| 9/10/2022 | Virginia-Wise | 17 | at | North Alabama (1-10) | 49 | at ASUN | ||
| 9/17/2022 | Barton (4-7,3-6) | 40 | at | Virginia-Wise | 20 | |||
| 9/24/2022 | Virginia-Wise | 13 | at | Limestone (8-4,7-2) | 27 | |||
| 9/30/2022 | Lenoir-Rhyne (8-3,7-2) | 42 | at | Virginia-Wise | 10 | |||
| 10/8/2022 | Virginia-Wise | 14 | at | Emory & Henry (5-6,4-5) | 34 | |||
| 10/15/2022 | Tusculum (8-3,6-3) | 10 | at | Virginia-Wise | 9 | |||
| 10/22/2022 | Virginia-Wise | 28 | at | Erskine (2-9,0-9) | 13 | |||
| 10/29/2022 | Mars Hill (7-3,7-2) | 20 | at | Virginia-Wise | 16 | |||
| 11/5/2022 | Virginia-Wise | 22 | at | Carson-Newman (6-5,5-4) | 38 | |||
| 11/12/2022 | Virginia-Wise | 7 | at | Wingate (11-3,7-2) | 45 |
| vs Virginia-Wise | vs Other Opponents | Virginia-Wise compared to OOs | |
| Record: | 9-2 | 52-60 | |
| Points Scored: | 29.73 | 25.80 | -3.93 |
| Points Allowed: | 17.91 | 26.09 | -8.18 |
| Margin: | 11.82 | -0.29 | -12.11 |
| Total Points: | 47.64 | 51.89 | -4.25 |