| 9/1/2022 | Mississippi Valley State | 13 | at | Tarleton State (6-5) | 29 | at WAC | ||
| 9/10/2022 | Mississippi Valley State | 0 | at | Austin Peay (7-4) | 41 | at ASUN | ||
| 9/17/2022 | Delta State (11-2) | 28 | at | Mississippi Valley State | 17 | GSC (D2) | ||
| 9/24/2022 | Mississippi Valley State | 7 | at | Jackson State (12-1,10-0) | 49 | |||
| 10/1/2022 | Mississippi Valley State | 7 | at | Florida A&M (9-2,7-1) | 34 | |||
| 10/8/2022 | Alcorn State (5-6,4-4) | 30 | at | Mississippi Valley State | 7 | |||
| 10/15/2022 | Mississippi Valley State | 9 | at | Alabama State (6-5,4-4) | 24 | |||
| 10/22/2022 | Bethune-Cookman (2-9,2-6) | 45 | at | Mississippi Valley State | 35 | |||
| 11/3/2022 | Alabama A&M (4-7,4-4) | 20 | at | Mississippi Valley State | 30 | |||
| 11/12/2022 | Mississippi Valley State | 7 | at | Southern (7-5,5-4) | 27 | |||
| 11/19/2022 | Prairie View (6-5,5-3) | 7 | at | Mississippi Valley State | 27 |
| vs Mississippi Valley State | vs Other Opponents | Mississippi Valley State compared to OOs | |
| Record: | 9-2 | 66-49 | |
| Points Scored: | 30.36 | 28.58 | -1.78 |
| Points Allowed: | 14.45 | 25.70 | -11.25 |
| Margin: | 15.91 | 2.88 | -13.03 |
| Total Points: | 44.81 | 54.28 | -9.47 |