| 9/1/2022 | Limestone (8-4) | 21 | at | Gardner-Webb | 56 | SAC (D2) | ||
| 9/10/2022 | Gardner-Webb | 27 | at | Coastal Carolina (9-4) | 31 | at SBC | ||
| 9/17/2022 | Gardner-Webb | 24 | at | Elon (8-4) | 30 | at CAAF | ||
| 9/24/2022 | Mercer (7-4) | 45 | at | Gardner-Webb | 14 | SoCon | ||
| 10/1/2022 | Gardner-Webb | 7 | at | Marshall (9-4) | 28 | at SBC | ||
| 10/8/2022 | Gardner-Webb | 48 | at | Robert Morris (0-11,0-5) | 0 | |||
| 10/15/2022 | Gardner-Webb | 20 | at | Liberty (8-5) | 21 | at Ind | ||
| 10/22/2022 | Gardner-Webb | 28 | at | Charleston Southern (2-8,2-3) | 14 | |||
| 10/29/2022 | Bryant (4-7,2-3) | 40 | at | Gardner-Webb | 48 | |||
| 11/12/2022 | Gardner-Webb | 42 | at | Campbell (5-6,2-3) | 35 | |||
| 11/19/2022 | North Carolina A&T (7-4,4-1) | 17 | at | Gardner-Webb | 38 | |||
| 11/26/2022 | Gardner-Webb | 52 | at | Eastern Kentucky (7-5) | 41 | FCS Championship - Round 1 | at ASUN | |
| 12/3/2022 | Gardner-Webb | 14 | at | William & Mary (11-2) | 54 | FCS Playoffs Round 2 | at CAAF |
| vs Gardner-Webb | vs Other Opponents | Gardner-Webb compared to OOs | |
| Record: | 6-7 | 79-61 | |
| Points Scored: | 29.00 | 28.79 | -0.21 |
| Points Allowed: | 32.15 | 26.77 | 5.38 |
| Margin: | -3.15 | 2.02 | 5.17 |
| Total Points: | 61.15 | 55.56 | 5.59 |